MFZ 10-7

MFZ 10-7 (3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile) is a drug with potential applications in the treatment of addiction, which acts as a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Others of the kind, namely MPEP & MTEP, are not considered to have translational potential for human use due to off-target effects and short half-lives. Drugs of this kind have been used to offset craving for drugs of abuse such as cocaine in in vivo animal administration models.[1]

MFZ 10-7
Identifiers
CAS Number
ChemSpider
ChEMBL
Chemical and physical data
FormulaC15H9FN2
Molar mass236.244
3D model (JSmol)

See also

References

  1. Keck TM, Zou MF, Bi GH, Zhang HY, Wang XF, Yang HJ, et al. (March 2014). "A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats". Addiction Biology. 19 (2): 195–209. doi:10.1111/adb.12086. PMC 3942387. PMID 24001208.
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