Lymphocytic interstitial pneumonia

Lymphocytic interstitial pneumonia (LIP) is a syndrome secondary to autoimmune and other lymphoproliferative disorders. Symptoms include fever, cough, and shortness of breath. Lymphocytic interstitial pneumonia applies to disorders associated with both monoclonal or polyclonal gammopathy.[1]

Lymphocytic interstitial pneumonia
Other namesLymphocytic interstitial pneumonitis
SpecialtyRespirology

Signs and symptoms

Patients with lymphocytic interstitial pneumonia may present with lymphadenopathy, enlarged liver, enlarged spleen, enlarged salivary gland, thickening and widening of the extremities of the fingers and toes (clubbing), and breathing symptoms such as shortness of breath and wheezing.

Causes

Possible causes of lymphocytic interstitial pneumonia include the Epstein-Barr virus and HIV.

Diagnosis
CT scan of lymphocytic interstitial pneumonia, with pulmonary cysts.

Arterial blood gases may reveal hypoxemia when tested in a lab. Respiratory alkalosis may also be present.[2] Peripheral lymphocytosis can be observed.[3] A lung biopsy may also be indicated.[4]

Treatment

Patients presenting with no symptoms, and not affected by the syndrome may not require treatment. Corticosteroids have been reported to be of benefit in select patients. Bronchodilators may assist with breathing issues and resolution may occur with the use of highly active anti-retroviral therapy. However, responses to different treatments are widely varied, and no single first line treatment represents the default treatment for lymphocytic interstitial pneumonia.[2]

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References
  1. Zander DS, Farver CF (2016-12-14). Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Health Sciences. p. 450. ISBN 978-0-323-46119-1.
  2. Teirstein AS, Rosen MJ (September 1988). "Lymphocytic interstitial pneumonia". Clin. Chest Med. 9 (3): 467–71. PMID 3044682.
  3. Pitt J (February 1991). "Lymphocytic interstitial pneumonia". Pediatr. Clin. North Am. 38 (1): 89–95. doi:10.1016/s0031-3955(16)38044-0. PMID 1987520.
  4. Strimlan CV, Rosenow EC, Weiland LH, Brown LR (May 1978). "Lymphocytic interstitial pneumonitis. Review of 13 cases". Ann. Intern. Med. 88 (5): 616–21. doi:10.7326/0003-4819-88-5-616. PMID 646244.
Classification
External resources
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