L-lysine cyclodeaminase

L-lysine cyclodeaminase (EC 4.3.1.28, rapL (gene), fkbL (gene), tubZ (gene), visC (gene)) is an enzyme with systematic name L-lysine ammonia-lyase (cyclizing; ammonia-forming).[1][2][3] This enzyme catalyses the following chemical reaction

L-lysine L-pipecolate + NH3
L-lysine cyclodeaminase
Identifiers
EC number4.3.1.28
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme requires bound NAD+.

References

  1. Khaw LE, Böhm GA, Metcalfe S, Staunton J, Leadlay PF (February 1998). "Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase". Journal of Bacteriology. 180 (4): 809–14. PMC 106958. PMID 9473033.
  2. Gatto GJ, Boyne MT, Kelleher NL, Walsh CT (March 2006). "Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster". Journal of the American Chemical Society. 128 (11): 3838–47. doi:10.1021/ja0587603. PMID 16536560.
  3. Tsotsou GE, Barbirato F (May 2007). "Biochemical characterisation of recombinant Streptomyces pristinaespiralis L-lysine cyclodeaminase". Biochimie. 89 (5): 591–604. doi:10.1016/j.biochi.2006.12.008. PMID 17291665.
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