Kaempferide

Kaempferide
Names
	IUPAC name 3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one
	Other names Kaempferid; 4'-Methylkaempferol; Kaempferol 4'-methyl ether; 4'-O-Methylkaempferol
Identifiers
CAS Number	491-54-3 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEBI	CHEBI:6099 ;
ChEMBL	ChEMBL40919 ;
ChemSpider	4444985 ;
ECHA InfoCard	100.007.036
KEGG	C10098 ;
PubChem CID	5281666;
UNII	508XL61MPD ;
CompTox Dashboard (EPA)	DTXSID9034155 ;
	InChI InChI=1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3 Key: SQFSKOYWJBQGKQ-UHFFFAOYSA-N ; InChI=1/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3 Key: SQFSKOYWJBQGKQ-UHFFFAOYAC;
	SMILES COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O; COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O;
Properties
Chemical formula	C16H12O6
Molar mass	300.26 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). It has been noted to inhibit pancreatic cancer growth by blockading an EGFR-related pathway.[1]

Metabolism

The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide.

Glycosides

Icariin is the tert-amyl alcohol derivative of kaempferide 3,7-O-diglycoside.

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References

Lee, Jungwhoi; Kim, Jae Hoon (2016). "Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro". PLOS ONE. 11 (5): e0155264. doi:10.1371/journal.pone.0155264. PMC 4866780. PMID 27175782.

External links

Kaempferide at the HMDB

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[1] Lee, Jungwhoi; Kim, Jae Hoon (2016). "Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro". PLOS ONE. 11 (5): e0155264. doi:10.1371/journal.pone.0155264. PMC 4866780. PMID 27175782.