Justin Yerbury

Justin John Yerbury AM (born 1974) is an Australian molecular biologist who was spurred to follow a career in biological research when he discovered his family has the genetic form of motor neuron disease (MND). He holds the position of Professor in Neurodegenerative Disease at the University of Wollongong. He was diagnosed with MND himself in 2016 but continues to research.

Justin John Yerbury

AM
Born1974 (age 45–46)
Wollongong, New South Wales, Australia
NationalityAustralian
EducationBSc (Hons 1st class), University of Wollongong; PhD, University of Wollongong
OccupationMolecular biologist
Medical career
InstitutionsIllawarra Health and Medical Research Institute (IHMRI), University of Wollongong
Sub-specialtiesResearch into the causes of MND
ResearchProtein misfolding and protein homeostasis
AwardsThe Australian Society for Medical Research Young Investigator Award, 2004;

Bill Gole Postdoctoral MND Research Fellowship, 2009; Vice Chancellor’s Emerging Researcher of the Year award, 2011; Lorne Conference on Protein Structure and Function Young Investigator Prize, 2012;

MND Australia Betty Laidlaw MND Research Prize for 2017

Education and career

By his own admission, Yerbury "was not much of a scientist at school."[1] He studied for a Bachelor of Commerce before playing professional basketball[2] in the National Basketball League (NBL) for the Illawarra Hawks in 1995 and 1996[3] while helping to run the family business.[2]

In the late 1990s members of Yerbury's extended family were diagnosed and died from motor neurone disease, also known as amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease. Ninety to ninety-five per cent of cases are considered sporadic, occurring randomly in the population. The remaining 5–10% of cases are familial (genetic) with one parent carrying the gene. Mutations of more than twelve genes have been found to cause the disease.[4] Using genealogical information Yerbury traced suspected cases of motor neuron disease in his family to at least 1920 and possibly further back.[5][2] He was prompted to return to university studies to further understand the disease.

In 2004 Yerbury obtained a BSc with 1st class honours from the University of Wollongong.[6] He received his PhD from the same university in 2008 for a thesis titled: Characterisation of novel extracellular molecular chaperones and their effects on amyloid formation.[7] He worked as a research assistant, lecturer and research fellow during his studies. During 2008 and 2009 he was an Australian Research Council (ARC) International Linkage Fellow at the University of Cambridge, UK. Yerbury has been a Discovery Early Career Researcher Award (DECRA) Postdoctoral Fellow at the University of Wollongong since 2012. He has spent the last decade studying the disease which affects around 2000 Australians, alongside his team at the Illawarra Health and Medical Research Institute (IHMRI), based at the University of Wollongong.[8] His team of young researchers will carry on his work.[1]

Personal life

Yerbury first knew of MND when his uncle was diagnosed in 1994. A cousin was diagnosed and died in 1997; he was 21 years old. During six-week period in 2002 his mother, grandmother and aunt died. Fifty per cent of Yerbury's family carry a faulty SOD-1 gene. His youngest sister died from MND at 26 years old. Yerbury and his sister, Naomi, were tested for the gene; Naomi was clear but Yerbury's test was positive.[5]

Yerbury was diagnosed with MND in 2016.[9] His condition stabilised at first but he now requires around-the-clock care and has a ventilator to allow him to breathe. He was initially denied a suitable wheelchair and house modifications under the National Disability Insurance Scheme (NDIS), sparking an online crowdfunding campaign.[10] After coming to the attention of Federal Labor MP Sharon Bird, he was provided with an appropriate wheelchair and some home modifications under the scheme.[9] Yerbury's public profile has also highlighted others who encountered difficulties with the NDIS.[9] Yebury highlighted the difficulties MND patients encounter with the NDIS in an article in The Conversation in November 2018.

A problem at the core of all MND-related difficulties with the NDIS is that the projected short lifespan of those with MND makes the NDIS baulk at funding high-cost items and modifications. We are not perceived as being “value for money”.

— Justin Yerbury, The Conversation, November 5, 2018[11]

In January 2018 Yerbury's condition deteriorated significantly and he underwent a tracheostomy necessitating mandatory ventilation. To further facilitate his life support he also had a laryngectomy which means he is unable to speak. He now communicates by lip reading and using voice software coordinated by eye-gaze on his laptop computer.[5] After this surgery Yerbury spent six months in hospital recovering with complications. In November 2018 he had returned home and began attending his office two days a week to continue his research.[12]

In April 2017 Yerbury met Stephen Hawking, a world-famous physicist and cosmologist who had MND for over fifty years until his death in 2018. They discussed living with the disease and Yerbury's research.[8][13][1]

Yerbury is married to Rachel Yerbury. They have two daughters born 1996, and 1998.

In March 2019 Yerbury, his family and carers were turned away from a planned cruise to New Caledonia because of a perceived "disability risk". After media attention the cruise company apologised to the family and refunded fees and costs.[14][15]

In December 2019 QANTAS airlines co-operated with the Yerbury family to provide an appropriate hoist to enable him to travel by plane to Perth, WA for a family holiday and to enable Yerbury to present his current research at the 30th International Symposium on ALS/MND.[16][17]

Research

“It was clear at the time that there was not enough understanding of the molecular basis of the disease to develop an effective therapeutic. I have, as a result dedicated myself to increasing the understanding of the origins of motor neurone disease.”

— Dr Justin Yerbury, [18]

Yerbury is researching potential effective treatments for MND. His research interests include: protein misfolding, aggregation and neurodegenerative disease, protein aggregation and neuro-inflammation and the Propagation of protein misfolding, and protein homeostasis and Motor Neurone Disease.[6] This video shows Yerbury demonstrating the role of protein folding in the progress of MND.[19] His team studies single molecules of protein, grow cells and are carrying out some drug trials.[20] He has been active in sharing his research not only with the academic community but also with those with MND and their families.[21][22]

Yerbury has 55 research articles listed in PubMed[23] in addition to many conference and other presentations.

Awards
  • The Australian Society for Medical Research Young Investigator Award, 2004[6]
  • Bill Gole Postdoctoral MND Research Fellowship, 2009[6][24]
  • Vice Chancellor's Emerging Researcher of the Year award, 2011[25]
  • Lorne Conference on Protein Structure and Function Young Investigator Prize, 2012[26]
  • MND Australia Betty Laidlaw MND Research Prize for 2017[27][18][28]
  • Wollongong’s Citizen of the Year, Australia Day Awards 2019[29]
  • Yerbury was made a Member of the Order of Australia in the 2020 Australia Day Honours for "significant service to education and research in the field of biological sciences."[30]
gollark: Physical buildings are sometimes useful, as some stuff is irritating/worse/impractical online.
gollark: They said "thanks for your input", asked for a new dress code, and ignored it.
gollark: > can males wear a skirt<@356107472269869058> My friend (not baidicolt) asked them to make the dress code more gender neutral, but they didn't really.
gollark: Make esolang .<@319753218592866315> .
gollark: They are apioforms with quantum computers.

References
  1. "Justin Yerbury has motor neurone disease. Now he's racing against time to find a cure". ABC News. 26 March 2018. Retrieved 27 March 2018.
  2. Australian Broadcasting Corporation, (ABC). "Motor Neurone Disease - my family's story - Health & Wellbeing". www.abc.net.au. Retrieved 28 March 2018.
  3. "Justin Yerbury - Player Statistics". SportsTG. Retrieved 28 March 2018.
  4. "Amyotrophic Lateral Sclerosis (ALS) Fact Sheet | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. Retrieved 28 March 2018.
  5. The Enemy Within: Australian Story episode. (includes transcript), Australian Broadcasting Corporation, 21 March 2018, retrieved 28 March 2018
  6. "Dr Justin Yerbury". smah.uow.edu.au. hallingu. Retrieved 28 March 2018.CS1 maint: others (link)
  7. Yerbury, Justin J. (2007). Characterisation of novel extracellular molecular chaperones and their effects on amyloid formation. Thesis (Ph.D.)--University of Wollongong, 2007. University of Wollongong.
  8. Wachsmuth, Lisa (26 March 2018). "MND researcher Dr Justin Yerbury fights for a cure – and his life". Illawarra Mercury. Retrieved 28 March 2018.
  9. "Concerns motor neurone patients slipping through cracks". ABC News. 10 March 2018. Retrieved 28 March 2018.
  10. "Fundraising for Justin organised by Naomi Yerbury". gofundme.com. Retrieved 28 March 2018.
  11. Yerbury, Justin. "Some diseases, like mine, deteriorate rapidly – disability services need to keep up". The Conversation. Retrieved 10 November 2018.
  12. No Surrender, Australian Story episode (includes transcript), Australian Broadcasting Corporation, 1 November 2018, retrieved 10 November 2018
  13. "How Stephen Hawking inspired me to take drastic measures against motor neurone disease". ABC News. 26 March 2018. Retrieved 28 March 2018.
  14. Judd, Bridget (10 March 2019). "Motor neurone disease expert turned away from cruise due to disability". ABC News. Retrieved 6 December 2019.
  15. Wachsmuth, Lisa (17 September 2019). "Wollongong scientist Justin Yerbury settles with Royal Caribbean after cruise debacle". Illawarra Mercury. Retrieved 6 December 2019.
  16. Drewitt-Smith, Ainslie; Rheinberger, Nick (28 November 2019). "Three seats, custom hoist let doctor trapped in own body fly again". ABC News. Retrieved 6 December 2019.
  17. ""The fine balance of proteostasis and its implications for ALS" presented by Professor Justin Yerbury". International Symposium on MND/ALS. 4 December 2019. Retrieved 6 December 2019.
  18. "IHMRI scientist wins motor neurone disease research prize". media.uow.edu.au. benl. Retrieved 28 March 2018.CS1 maint: others (link)
  19. University of Wollongong (3 July 2014), Budding Ideas - May 2014 - Dr Justin Yerbury, retrieved 28 March 2018
  20. UOWTV Multimedia (5 May 2014), National Motor Neurone Disease Week, retrieved 28 March 2018
  21. The Motor Neurone Disease Association of NSW (4 August 2015), 2015 Ask the Experts 3 What's new in MND Research? Part A - Dr Justin Yerbury, retrieved 28 March 2018
  22. The Motor Neurone Disease Association of NSW (4 August 2015), 2015 Ask the Experts 4 What's new in MND Research? Part B Questions - Dr Justin Yerbury, retrieved 28 March 2018
  23. "Justin Yerbury - PubMed - NCBI". www.ncbi.nlm.nih.gov. Retrieved 10 November 2018.
  24. "MND research fellowships and scholarships". Motor Neurone Disease Research Institute of Australia Annual Review: 5. December 2008.
  25. "VC Awards 2011 Recipients". www.uow.edu.au. aclode. Retrieved 28 March 2018.CS1 maint: others (link)
  26. "Past Award Winners » Lorne Proteins". www.lorneproteins.org. Retrieved 28 March 2018.
  27. "NSW researcher awarded MND Research Prize for 2017". www.mndnsw.asn.au. Retrieved 28 March 2018.
  28. "MND research grants". MND Australia. Retrieved 28 March 2018.
  29. Tullis, Ashleigh (22 January 2019). "Motor Neurone Disease advocate and sufferer named Wollongong's Citizen of the Year". Illawarra Mercury. Retrieved 24 January 2019.
  30. Stehle, Mark (25 January 2020). "Australia Day Honours 2020: Full list of recipients". Sydney Morning Herald. Nine Entertainment Co. Retrieved 25 January 2020.
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