Irene Uchida

Irene Ayako Uchida, OC (April 8, 1917 – July 30, 2013) was a Canadian scientist and Down syndrome researcher.

Irene Ayako Uchida
Born(1917-04-08)April 8, 1917
Vancouver, British Columbia, Canada
DiedJuly 30, 2013(2013-07-30) (aged 96)
Toronto, Ontario, Canada
EducationUniversity of British Columbia
University of Toronto
OccupationGeneticist
  • "Science is a rewarding and challenging career. Young people going into science must keep an open mind to all ideas in an effort to find every possible way to help people." -Irene Uchida

Born in Vancouver, she initially studied English literature at the University of British Columbia. As a child and teenager she played violin and piano, and was described as "out-going" and "social." She went to visit her mother and sister who were in Japan at the time, and was able to catch a ship out of Japan prior to the Japanese attack on Pearl Harbor on December 1941.

In Canada, she and her family were sent to an internment camp in the Slocan Valley during World War II.[1]

In 1944 she continued her studies at the University of Toronto where she wanted to get a master's degree in social work. Her professors encouraged her to pursue a career in genetics, and as a result she completed PhD in human genetics at the University of Toronto in 1951 and worked at the Hospital for Sick Children in Toronto. At the Hospital for Sick Children she studied twins and children with Down syndrome. In the 1960s she helped identify the link between pregnant women who had undergone abdominal X-rays and chromosomal birth defects such as Down syndrome in their subsequent pregnancies.[2] She was also amongst those researchers in the 1960s who showed that the extra chromosome associated with Down Syndrome is not always from the mother, but he father may be responsible for 25 per cent of the births.

In 1960 she became the director of the Department of Medical Genetics at the Children’s Hospital in Winnipeg and became a professor at the University of Manitoba (National Library of Canada and National Archives of Canada, 1997). She moved to McMaster University, in Hamilton, Ontario, in 1969, where she was a professor or pediatrics and pathology and directory of the cytogenetics lab until she retired in 1985.

In 1993, she was made an Officer of the Order of Canada for "her research on radiation and human chromosome abnormalities [that] has made a notable contribution to medical science".[3]

Early life

Irene Uchida, the daughter of Japanese immigrants, was born in Vancouver, B.C., Canada. She has been described as feisty, fun-loving, and opinionated. Though originally named "Ayako," which means "Splendid" in Japanese, Irene's piano teacher found it too difficult to pronounce and so gave her the name "Irene." Irene was an accomplished musician and played violin and organ in addition to the piano.[4]

During her childhood in Vancouver, Irene experienced the tragic loss of her best friend in a traffic accident. Around this same time, she also lost her sister Sachi who died of Tuberculosis. These losses instilled in Irene the desire to help people, which is something she worked toward for the rest of her life.

Education

Irene's parents owned two bookstores, so it is fitting that after high school she went on to study English literature at the University of British Columbia. Her education was interrupted, however, after she travelled with her mother and sisters to Japan in 1941. She returned on the last ship back to Canada before the attack on Pearl Harbor that year, her mother and sisters remaining in Japan. Because of the war and the fear it created that the Japanese minority in Canada were a security threat, Irene and her family members who were still in Canada were forced to leave their home and live in an internment camp at Christina Lake, British Columbia.

While in this internment camp, Irene was asked to be the principal of a school for children of internees because of her university education. After her father chose to return to his wife in Japan as an exchange for Allied prisoners of war, Irene accepted the support of the United Church, which offered her a place to stay and encouraged her to finish her degree at University of Toronto. Uchida earned a Bachelor of Arts in 1946, intending to continue her education by getting a Master's degree in social work.

The support and encouragement of one of her professors, Norma Ford Walker, head of the Department of Zoology but soon to become the director of a newly formed Department of Genetics at the Hospital for Sick Children in Toronto, however, influenced Uchida to instead pursue the field of human genetics. In 1951 she completed her PhD in zoology.[5]

Career

After she finished her PhD, Uchida went to work at the Hospital for Sick Children in Toronto and began studying twins and children with Down syndrome, which was the most common severe birth abnormality at the time. She spent a year working on Drosophila chromosomes, training with Dr. Klaus Patau at the University of Wisconsin, who later discovered trisomy 13, initially dubbed Patau’s syndrome.[5]

In 1960, Dr. Uchida was appointed Director of the Department of Medical Genetics at the Children's Hospital in Winnipeg, Manitoba and began teaching at University of Manitoba. After scientists in France discovered that people with Down syndrome had 47 chromosomes instead of the normal 46, she decided to investigate the cause of the extra chromosome. Cytogenetics, the study of chromosomes in cells, focuses on the identification and behavior of chromosomes, and Dr. Uchida was the first scientist to bring this technique to Canada. During ward rounds in the nursery to discuss cytogenetics of Down syndrome as well as a birth-defect syndrome found to be caused by trisomy 18, Dr. Uchida investigated the possibility of a newborn with this birth defect. She persuaded her lab, then studying chromosomes of fruit flies, to study the chromosomes from the blood sample taken from the nursery, found trisomy, and started Canada's first clinical cytogenetics program.[5]

In her career as a professor at University of Manitoba, Dr. Uchida facilitated two studies to investigate a possible connection between extensive maternal radiation and Down syndrome births. The studies she conducted involved 972 children in each category studied, and she found strong evidence that abdominal x-ray exposure led to nondisjunction in their pregnancies and risk of birth defects.

Dr. Uchida was the director of the Cytogenetics Laboratory in Oshawa, Ontario, and was responsible for diagnosing chromosome differences in patients with abnormalities and developmental disabilities as well as diagnosed irregularities in the chromosomes of fetuses.

In 1970, Dr. Uchida founded the Cytogenetics Laboratory at McMaster University in Hamilton, Ontario. Her expertise in genetics led to her become the President of the American Society of Human Genetics in 1960, a member of the Science Council of Canada from 1970-1973, a member of the Advisory Committee on Genetic Services for Ontario in 1979, a consultant to the American Board of Medical Genetics in 1980, and a member of the Canadian College of Medical Geneticists from 1980-1984, among other things.

Dr. Uchida published more than 95 scientific papers and received numerous awards for her research including Woman of the Century 1867-1967 for Manitoba and the Order of Canada in 1993.[6]

Death

After suffering from dementia for over a decade, Irene died in a nursing home in Toronto on July 30, 2013 at the age of 96.

gollark: I think I could do a better job. I at least know how to parse things, and how stacks work.
gollark: Clearly your slightly messed up grammar/spelling parsing is not ideal?
gollark: Indeed!
gollark: A stack is just a special case of a tree.
gollark: <@!332271551481118732> I meant "practical" in the sense of "I can actually write it".

References
  1. Plokhii O (13 September 2013). "Irene Uchida, world-renowned leader in genetics research". The Globe and Mail. Retrieved 2018-03-26.
  2. "Irene Ayako Uchida". Science.ca. Retrieved 2018-04-07.
  3. Order of Canada citation
  4. Davidson, Ronald G. (2013-10-03). "Irene A. Uchida, 1917–2013". The American Journal of Human Genetics. 93 (4): 591–594. doi:10.1016/j.ajhg.2013.09.005. ISSN 0002-9297. PMC 3791260.
  5. Rosen R (December 1986). ""Role of mathematical modeling in protocol formulation in cancer chemotherapy"". Cancer Treatment Reports. 70 (12): 1461–2. doi:10.1016/j.ajhg.2013.09.005. PMC 3791260.
  6. Nolan, Daniel (2013-09-08). "Passages: Renowned geneticist began from scratch after internment". The Hamilton Spectator. ISSN 1189-9417. Retrieved 2019-02-05.
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