Human polyomavirus 12

Human polyomavirus 12 (HPyV12) is a virus of the polyomavirus family that infects human hosts. It was discovered and reported in 2013 after isolation from the organs of the gastrointestinal tract, particularly the liver.[1] The virus was renamed to Sorex araneus polyomavirus 1 in 2018.

Sorex araneus polyomavirus 1
Virus classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Sepolyvirales
Family: Polyomaviridae
Genus: Alphapolyomavirus
Species:
Sorex araneus polyomavirus 1

Discovery

HPyV12 was first discovered in 2013 by generic PCR used to screen samples of the organs of the gastrointestinal tract. HPyV12 was identified first and most commonly in liver samples; it was also occasionally detected in the colon and rectum and in feces.[1]

Taxonomy

The HPyV12 genome follows the typical organization for a polyomavirus, containing a small and large tumor antigen and three viral capsid proteins; it has no open reading frame corresponding to an agnoprotein. In the 2015 taxonomic update to the polyomavirus group, the International Committee on Taxonomy of Viruses classified HPyV12 as a member of the genus Alphapolyomaviridae, whose type species is murine polyomavirus (Mus musculus polyomavirus 1).[2] In 2018, it was renamed to Sorex araneus polyomavirus 1.

Prevalence

The prevalence of HPyV12 is not well characterized. A survey of seroprevalence — that is, prevalence of detectable antibodies against viral proteins indicating either past or present exposure — found that between 15–33% of healthy adults exhibited evidence of exposure, with slightly lower rates in children.[1]

Clinical manifestations

There is no known clinical significance associated with HPyV12.[3]

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References
  1. Korup, Sarah; Rietscher, Janita; Calvignac-Spencer, Sébastien; Trusch, Franziska; Hofmann, Jörg; Moens, Ugo; Sauer, Igor; Voigt, Sebastian; Schmuck, Rosa; Ehlers, Bernhard; Qiu, Jianming (13 March 2013). "Identification of a Novel Human Polyomavirus in Organs of the Gastrointestinal Tract". PLoS ONE. 8 (3): e58021. doi:10.1371/journal.pone.0058021. PMC 3596337. PMID 23516426.
  2. Polyomaviridae Study Group of the International Committee on Taxonomy of, Viruses; Calvignac-Spencer, S; Feltkamp, MC; Daugherty, MD; Moens, U; Ramqvist, T; Johne, R; Ehlers, B (29 February 2016). "A taxonomy update for the family Polyomaviridae". Archives of Virology. 161 (6): 1739–50. doi:10.1007/s00705-016-2794-y. PMID 26923930.
  3. Rinaldo, Christine Hanssen; Hirsch, Hans H. (August 2013). "The human polyomaviruses: from orphans and mutants to patchwork family". APMIS. 121 (8): 681–4. doi:10.1111/apm.12125. PMID 23781946.

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