History of syphilis

The first recorded outbreak of syphilis in Europe occurred in 1494/1495 in Naples, Italy, during a French invasion.[1][2] Because it was spread by returning French troops, the disease was known as "French disease", and it was not until 1530 that the term "syphilis" was first applied by the Italian physician and poet Girolamo Fracastoro.[2] The causative organism, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann in 1905.[2] The first effective treatment, Salvarsan, was developed in 1910 by Sahachirō Hata in the laboratory of Paul Ehrlich. It was followed by the introduction of penicillin in 1943.[2]

The earliest known medical illustration of people with syphilis, Vienna, 1498

Many well-known figures, including Scott Joplin, Franz Schubert, Friedrich Nietsche, Al Capone, and Édouard Manet are believed to have contracted the disease.[2]

Origin

The history of syphilis has been well studied, but the exact origin of the disease remains unknown.[3] There are two primary hypotheses: one proposes that syphilis was carried to Europe from the Americas by the crew(s) of Christopher Columbus as a byproduct of the Columbian exchange, while the other proposes that syphilis previously existed in Europe but went unrecognized.[1] These are referred to as the "Columbian" and "pre-Columbian" hypotheses.[1]

Syphilis is the first "new" disease to be discovered after the invention of printing. News of it spread quickly and widely, and documentation is abundant. For the time, it was "front page news" that was widely known among the literate. It is also the first disease to be widely recognized as a sexually transmitted disease, and it was taken as indicative of the moral state (sexual behavior) of the peoples in which it was found. Its geographic origin and moral significance were debated as had never been the case with any other illness. European countries blamed it on each other. Somewhat later, when the significance of the Western Hemisphere was perceived, it has been used in both pro- and anti-colonial discourse.

The historical origin of syphilis has modern implications.[4] The arrival of Europeans in the New World resulted in the damaging effects of colonialism and the spread of deadly diseases like smallpox that European explorers unintentionally brought to the Americas. According to biologist Marlene Zuk, "The origin of syphilis has always held an implied accusation: if Europeans brought it to the New World, the disease is one more symbol of Western imperialism run amok, one more grudge to hold against colonialism."[4]

Columbian theory

This common theory[5] holds that syphilis was a New World disease brought back by Columbus, Martín Alonso Pinzón, and/or other members of their crews as an unintentional part of the Columbian Exchange. Columbus's first voyages to the Americas occurred three years before the Naples syphilis outbreak of 1495.[1] Exactly 538 skeletal remains in the Dominican Republic have shown evidence characteristic of treponemal disease in 6–14% of the afflicted population, which Rothschild and colleagues have postulated was syphilis.[6] The Aztec god Nanahuatzin is often interpreted as suffering from syphilis.[7]

The 2011 Yearbook of Physical Anthropology published an appraisal by Harper and colleagues, of previous studies and stated that the "skeletal data bolsters the case that syphilis did not exist in Europe before Columbus set sail."[8] The scientific evidence as determined by a systematic review of 54 previously published, peer-reviewed instances lends support to the theory that syphilis was unknown in Europe until Columbus returned from the Americas. According to this appraisal, "Skeletal evidence that reputedly showed signs of syphilis in Europe and other parts of the Old World before Christopher Columbus made his voyage in 1492 does not hold up when subjected to standardized analyses for diagnosis and dating, according to an appraisal in the current Yearbook of Physical Anthropology. This is the first time that all 54 previously published cases have been evaluated systematically, and bolsters the case that syphilis came from the New World."[9] In an article criticizing the presentation of new research findings in PBS and BBC documentaries about syphilis, researchers said they showed "a blatant disregard for the peer review process in making the case for pre-Columbian syphilis in the Old World. [...] As in all scientific fields, in order to resolve the controversy over the origin and antiquity of syphilis in the Old World, there is a strong need for adherence to standard practice in scientific publication and the increased publication of relevant evidence in peer-reviewed journals."[10]

Pre-Columbian theory

The theory holds that syphilis was present in Europe before the arrival of Europeans in the Americas. Some scholars during the 18th and 19th centuries believed that the symptoms of syphilis in its tertiary form were described by Hippocrates in Classical Greece.[11] Skeletons in pre-Columbus Pompeii and Metaponto in Italy with damage similar to that caused by congenital syphilis have also been found.[12][13][14] Douglas W. Owsley, a physical anthropologist at the Smithsonian Institution, and other supporters of this idea, say that many medieval European cases of leprosy, colloquially called lepra, were actually cases of syphilis. However, these claims have not been submitted for peer review, and the evidence that has been made available to other scientists is weak.[10] Although folklore claimed that syphilis was unknown in Europe until the return of the diseased sailors of the Columbian voyages, Owsley says that "syphilis probably cannot be 'blamed'—as it often is—on any geographical area or specific race. The evidence suggests that the disease existed in both hemispheres from prehistoric times. It is only coincidental with the Columbus expeditions that the syphilis previously thought of as 'lepra' flared into virulence at the end of the 15th century."[15] Lobdell and Owsley wrote that a European writer who recorded an outbreak of "lepra" in 1303 was "clearly describing syphilis."[15] In 2015, researchers discovered 14th-century skeletons in Austria that they say show signs of congenital syphilis, which is transmitted from mother to child rather than sexually.[16] In 2020 DNA analysis of nine infected skeletons defend the "pre-Columbian" hypotheses, but is short of conclusive.[17]

Combination theory

Historian Alfred Crosby suggested in 2003 that both theories are partly correct in a "combination theory". Crosby says that the bacterium that causes syphilis belongs to the same phylogenetic family as the bacteria that cause yaws and several other diseases. Despite the tradition of assigning the homeland of yaws to sub-Saharan Africa, Crosby notes that there is no unequivocal evidence of any related disease having been present in pre-Columbian Europe, Africa, or Asia. Crosby writes, "It is not impossible that the organisms causing treponematosis arrived from America in the 1490s ... and evolved into both venereal and non-venereal syphilis and yaws."[18] However, Crosby considers it more likely that a highly contagious ancestral species of the bacteria moved with early human ancestors across the land bridge of the Bering Straits many thousands of years ago without dying out in the original source population. He hypothesizes that "the differing ecological conditions produced different types of treponematosis and, in time, closely related but different diseases."[18] A more recent, modified version of the Columbian theory that better fits skeletal evidence from the New World, and also "absolved the New World of being the birthplace of syphilis", proposes that a nonvenereal form of treponemal disease, without the lesions common to congenital syphilis, was brought back to Europe by Columbus and his crew. Upon arrival in the Old World, the bacterium, which was similar to modern day yaws, responded to new selective pressures with the eventual birth of the subspecies of sexually transmitted syphilis.[10] This theory is supported by genetic studies of venereal syphilis and related bacteria, which found a disease intermediate between yaws and syphilis in Guyana, South America.[19][20] However, the study has been criticized in part because some of its conclusions were based on a tiny number of sequence differences between the Guyana strains and other treponemes whose sequences were examined.[10][21]

European outbreak
A medical illustration attributed to Albrecht Dürer (1496) depicting a person with syphilis. Here, the disease is believed to have astrological causes.

The first well-recorded European outbreak of what is now known as syphilis occurred in 1495 among French troops besieging Naples, Italy.[1] It may have been transmitted to the French via Spanish mercenaries serving King Charles of France in that siege.[15] From this centre, the disease swept across Europe. As Jared Diamond describes it, "[W]hen syphilis was first definitely recorded in Europe in 1495, its pustules often covered the body from the head to the knees, caused flesh to fall from people's faces, and led to death within a few months." The disease then was much more lethal than it is today.[22] The epidemiology of this first syphilis epidemic shows that the disease was either new or a mutated form of an earlier disease.

Some researchers argue that syphilis was carried from the New World to Europe after Columbus' voyages, while others argue the disease has a much longer history in Europe. Many of the crew members who served on this voyage later joined the army of King Charles VIII in his invasion of Italy in 1495, which some argue may have resulted in the spreading of the disease across Europe and as many as five million deaths.[20] Some findings suggest Europeans could have carried the nonvenereal tropical bacteria home, where the organisms may have mutated into a more deadly form in the different conditions and low immunity of the population of Europe.[23] Syphilis was a major killer in Europe during the Renaissance.[24] In his Serpentine Malady (Seville, 1539) Ruy Díaz de Isla estimated that over a million people were infected in Europe. He also postulated that the disease was previously unknown, and came from the island of Hispaniola (modern Dominican Republic and Haiti).[25]

According to a 2020 study, more than 20% of individual in the age range 15–34 years in late 18th century London were treated for syphilis.[26]

Historical terms

The name "syphilis" was coined by the Italian physician and poet Girolamo Fracastoro in his pastoral noted poem, written in Latin, titled Syphilis sive morbus gallicus (Latin for "Syphilis or The French Disease") in 1530.[2][27] The protagonist of the poem is a shepherd named Syphilus (perhaps a variant spelling of Sipylus, a character in Ovid's Metamorphoses). Syphilus is presented as the first man to contract the disease, sent by the god Apollo as punishment for the defiance that Syphilus and his followers had shown him.[2] From this character Fracastoro derived a new name for the disease, which he also used in his medical text De Contagione et Contagiosis Morbis (1546) ("On Contagion and Contagious Diseases").[28]

Until that time, as Fracastoro notes, syphilis had been called the "French disease" (Italian: mal francese) in Italy, Malta,[29] Poland and Germany, and the "Italian disease" in France. In addition, the Dutch called it the "Spanish disease", the Russians called it the "Polish disease", and the Turks called it the "Christian disease" or "Frank (Western European) disease" (frengi). These "national" names were generally reflective of contemporary political spite between nations and frequently served as a sort of propaganda; the Protestant Dutch, for example, fought and eventually won a war of independence against their Spanish Habsburg rulers who were Catholic, so referring to Syphilis as the "Spanish" disease reinforced a politically useful perception that the Spanish were immoral or unworthy. However, the attributions are also suggestive of possible routes of the spread of the infection, at least as perceived by "recipient" populations. The inherent xenophobia of the terms also stemmed from the disease's particular epidemiology, often being spread by foreign sailors and soldiers during their frequent sexual contact with local prostitutes.[30]

During the 16th century, it was called "great pox" in order to distinguish it from smallpox. In its early stages, the great pox produced a rash similar to smallpox (also known as variola). However, the name is misleading, as smallpox was a far more deadly disease. The terms "lues"[31] (or Lues venerea, Latin for "venereal plague") and "Cupid's disease"[32] have also been used to refer to syphilis. In Scotland, syphilis was referred to as the Grandgore or Spanyie Pockis.[33] The ulcers suffered by British soldiers in Portugal were termed "The Black Lion".[34]

Historical treatments
An artificial nose from the 17–18th century. Such cosmetic replacements were sometimes used due to effects of the disease.

There were originally no effective treatments for syphilis, although a number of remedies were tried. In the infant stages of this disease in Europe, many ineffective and dangerous treatments were used. The aim of treatment was to expel the foreign, disease-causing substance from the body, so methods included blood-letting, laxative use, and baths in wine and herbs or olive oil.[35]

Mercury was a common, long-standing treatment for syphilis, and its use as such has been suggested to date back to The Canon of Medicine (1025) by the Persian physician Ibn Sina (Avicenna);[36] although this is only possible if syphilis existed in the Old World prior to Columbus (see § Origin). One of the first supporters of mercury treatment was Paracelsus because it had positive effects on the Arabic treatment of leprosy, which was thought to be a disease related to syphilis.[37] Giorgio Sommariva of Verona is recorded to have used mercury to treat syphilis in 1496, and is often recognized as the first physician to have done so, although he may not have been a physician.[38] During the sixteenth century, mercury was administered to syphilitic patients in various ways, including by rubbing it on the skin, by applying a plaster, and by mouth.[39] A "Fumigation" method of administering mercury was also used, in which mercury was vaporized over a fire and the patients were exposed to the resulting steam, either by being placed in a bottomless seat over the hot coals, or by having their entire bodies except for the head enclosed in a box (called a "tabernacle") that received the steam.[39] The goal of mercury treatment was to cause the patient to salivate, which was thought to expel the disease. Unpleasant side effects of mercury treatment included gum ulcers and loose teeth.[39] Mercury continued to be used in syphilis treatment for centuries; an 1869 article by Thomas James Walker, M. D., discussed administering mercury by injection for this purpose.[40]

The discovery of guaiacum as cure for syphilis, after Stradanus, 1590

Guaiacum was a popular treatment in the sixteenth century and was strongly advocated by Ulrich von Hutten and others.[39] Because guaiacum came from Hispaniola where Columbus had landed, proponents of the Columbian theory contended that God had provided a cure in the same location from which the disease originated.[39] In 1525, the Spanish priest Francisco Delicado, who himself suffered from syphilis, wrote El modo de adoperare el legno de India occidentale (How to Use the Wood from the West Indies[41]) discussing the use of guaiacum for treatment of syphilis.[42] Although guaiacum did not have the unpleasant side effects of mercury, guaiacum was not particularly effective,[39] at least not beyond the short term,[42] and mercury was thought to be more effective.[39] Some physicians continued to use both mercury and guaiacum on patients. After 1522, the Blatterhaus—an Augsburg municipal hospital for the syphilitic poor[43]—would administer guaiacum (as a hot drink, followed by a sweating cure) as the first treatment, and use mercury as the treatment of last resort.[39]

Another sixteenth-century treatment advocated by the Italian physician Antonio Musa Brassavola was the oral administration of Root of China,[39] a form of sarsaparilla (Smilax).[44] In the seventeenth century, English physician and herbalist Nicholas Culpeper recommended the use of heartsease (wild pansy).[45]

Before effective treatments were available, syphilis could sometimes be disfiguring in the long term, leading to defects of the face and nose ("nasal collapse"). Syphilis was a stigmatized disease due to its sexually transmissible nature. Such defects marked the person as a social pariah, and a symbol of sexual deviancy. Artificial noses were sometimes used to improve this appearance. The pioneering work of the facial surgeon Gasparo Tagliacozzi in the 16th century marked one of the earliest attempts to surgically reconstruct nose defects. Before the invention of the free flap, only local tissue adjacent to the defect could be harvested for use, as the blood supply was a vital determining factor in the survival of the flap. Tagliacozzi's technique was to harvest tissue from the arm without removing its pedicle from the blood supply on the arm. The patient would have to stay with their arm strapped to their face until new blood vessels grew at the recipient site, and the flap could finally be separated from the arm during a second procedure.

An early technique for grafting tissue to surgically correct a nose defect.

As the disease became better understood, more effective treatments were found. An antimicrobial used for treating disease was the organo-arsenical drug Salvarsan, developed in 1908 by Sahachiro Hata in the laboratory of Nobel prize winner Paul Ehrlich. This group later discovered the related arsenic, Neosalvarsan, which is less toxic.[46]

It was observed that sometimes patients who developed high fevers were cured of syphilis. Thus, for a brief time malaria was used as treatment for tertiary syphilis because it produced prolonged and high fevers (a form of pyrotherapy). This was considered an acceptable risk because the malaria could later be treated with quinine, which was available at that time. Malaria as a treatment for syphilis was usually reserved for late disease, especially neurosyphilis, and then followed by either Salvarsan or Neosalvarsan as adjuvant therapy. This discovery was championed by Julius Wagner-Jauregg,[47] who won the 1927 Nobel Prize for Medicine for his discovery of the therapeutic value of malaria inoculation in the treatment of neurosyphilis. Later, hyperthermal cabinets (sweat-boxes) were used for the same purpose.[48] These treatments were finally rendered obsolete by the discovery of penicillin, and its widespread manufacture after World War II allowed syphilis to be effectively and reliably cured.[49]

History of diagnosis

In 1905, Schaudinn and Hoffmann discovered Treponema pallidum in tissue of patients with syphilis.[2] One year later, the first effective test for syphilis, the Wassermann test, was developed. Although it had some false positive results, it was a major advance in the detection and prevention of syphilis. By allowing testing before the acute symptoms of the disease had developed, this test allowed the prevention of transmission of syphilis to others, even though it did not provide a cure for those infected. In the 1930s the Hinton test, developed by William Augustus Hinton, and based on flocculation, was shown to have fewer false positive reactions than the Wassermann test.[50] Both of these early tests have been superseded by newer analytical methods.

While working at the Rockefeller University (then called the Rockefeller Institute for Medical Research) in 1913, Hideyo Noguchi, a Japanese scientist, demonstrated the presence of the spirochete Treponema pallidum in the brain of a progressive paralysis patient, associating Treponema pallidum with neurosyphilis.[51] Prior to Noguchi's discovery, syphilis had been a burden to humanity in many lands. Without its cause being understood, it was sometimes misdiagnosed and often misattributed to damage by political enemies. It is called "the great pretender" for its variety of symptoms. Felix Milgrom developed a test for syphilis. The Hideyo Noguchi Africa Prize was named to honor the man who identified the agent in association with the late form of the infectious disease.[52]

Arts and literature
Portrait of Gerard de Lairesse by Rembrandt van Rijn, ca. 1665–67, oil on canvas. De Lairesse, himself a painter and art theorist, suffered from congenital syphilis that severely deformed his face and eventually blinded him.[53]

The earliest known depiction of an individual with syphilis is Albrecht Dürer's Syphilitic Man, a woodcut believed to represent a Landsknecht, a Northern European mercenary.[54] The myth of the femme fatale or "poison women" of the 19th century is believed to be partly derived from the devastation of syphilis, with classic examples in literature including John Keats' La Belle Dame sans Merci.[55][56] Poet Sebastian Brandt in 1496 wrote a poem titled De pestilentiali Scorra sive mala de Franzos which explains the spread of the disease across the European continent.[57] Brandt also created artistic creations showing religious and political views of syphilis, especially with a work showing Saint Mary and Jesus throwing lightning to punish or cure those afflicted by syphilis, and he also added King Maximilian I in the work, being rewarded by Mary and Jesus for his work against the immoral disease, to show the strong relationship between church and state during the sixteenth and seventeenth centuries.[58]

The Flemish artist Stradanus designed a print of a wealthy man receiving treatment for syphilis with the tropical wood guaiacum sometime around 1580.[59] The title of the work is "Preparation and Use of Guayaco for Treating Syphilis". That the artist chose to include this image in a series of works celebrating the New World indicates how important a treatment, however ineffective, for syphilis was to the European elite at that time. The richly colored and detailed work depicts four servants preparing the concoction while a physician looks on, hiding something behind his back while the hapless patient drinks.[60] Another artistic depiction of syphilis treatment is credited to Jacques Laniet in the seventeenth century as he illustrated a man using the fumigation stove, another popular method of syphilis treatment, with a nearby barrel etched with the saying "For a pleasure, a thousand pains."[58] Remedies to cure syphilis were frequently illustrated to deter those from acts which could lead to the contraction of syphilis because the treatment methods were normally painful and ineffective.

Tuskegee and Guatemala studies
A Work Projects Administration poster about syphilis ca. 1940.

One of the most infamous United States cases of questionable medical ethics in the 20th century was the Tuskegee syphilis study.[61] The study took place in Tuskegee, Alabama, and was supported by the U.S. Public Health Service (PHS) in partnership with the Tuskegee Institute.[62] The study began in 1932, when syphilis was a widespread problem and there was no safe and effective treatment.[63] The study was designed to measure the progression of untreated syphilis. By 1947, penicillin had been shown to be an effective cure for early syphilis and was becoming widely used to treat the disease.[62] Its use in later syphilis, however, was still unclear.[63] Study directors continued the study and did not offer the participants treatment with penicillin.[62] This is debated, and some have found that penicillin was given to many of the subjects.[63]

In the 1960s, Peter Buxtun sent a letter to the CDC, who controlled the study, expressing concern about the ethics of letting hundreds of black men die of a disease that could be cured. The CDC asserted that it needed to continue the study until all of the men had died. In 1972, Buxtun went to the mainstream press, causing a public outcry. As a result, the program was terminated, a lawsuit brought those affected nine million dollars, and Congress created a commission empowered to write regulations to deter such abuses from occurring in the future.[62]

On 16 May 1997, thanks to the efforts of the Tuskegee Syphilis Study Legacy Committee formed in 1994, survivors of the study were invited to the White House to be present when President Bill Clinton apologized on behalf of the United States government for the study.[64]

Syphilis experiments were also carried out in Guatemala from 1946 to 1948. They were United States-sponsored human experiments, conducted during the government of Juan José Arévalo with the cooperation of some Guatemalan health ministries and officials. Doctors infected soldiers, prisoners, and mental patients with syphilis and other sexually transmitted diseases, without the informed consent of the subjects, and then treated them with antibiotics. In October 2010, the U.S. formally apologized to Guatemala for conducting these experiments.[65]

List of cases
Main article: List of syphilis cases

Eradication

In 2015, Cuba became the first country in the world to receive validation from WHO for eradicating mother to child transmission of syphilis.[66]

gollark: A true student of Pro.
gollark: Because their description ***LIES***.
gollark: I've only ever frozen one hatchling, to get a slot.
gollark: Recovery from what?
gollark: I'd like the chrono, but my only nebulon grew up a while ago.

See also

References
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