Heme ligase
Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming).[1] This enzyme catalyses the following chemical reaction
- 2 ferriprotoporphyrin IX beta-hematin
Heme ligase | |||||||||
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Identifiers | |||||||||
EC number | 4.99.1.8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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This heme detoxifying enzyme is found in Plasmodium parasites.
References
- Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D (April 2008). "HDP-a novel heme detoxification protein from the malaria parasite". PLoS Pathogens. 4 (4): e1000053. doi:10.1371/journal.ppat.1000053. PMC 2291572. PMID 18437218.
External links
- Heme+ligase at the US National Library of Medicine Medical Subject Headings (MeSH)
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