Heme ligase

Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming).[1] This enzyme catalyses the following chemical reaction

2 ferriprotoporphyrin IX beta-hematin
Heme ligase
Identifiers
EC number4.99.1.8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This heme detoxifying enzyme is found in Plasmodium parasites.

References

  1. Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D (April 2008). "HDP-a novel heme detoxification protein from the malaria parasite". PLoS Pathogens. 4 (4): e1000053. doi:10.1371/journal.ppat.1000053. PMC 2291572. PMID 18437218.
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