Helicase–primase complex

A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated factor protein may also be present.[1]

The complex is used by herpesviruses, in which it is responsible for lytic DNA virus replication.[2][3][4] In many dsDNA viruses, primase and helicase are fused into a single polypeptide chain, so that the primase and helicase domains correspond to the N-terminal and C-terminal parts of the protein, respectively.[5] A helicase-primase inhibitor (HPI) is a drug that blocks this action through acting as an enzyme inhibitor.

List of H-P by virus name
  • EBV: helicase:BBLF4 primase: BSLF1 accessory protein:BBLF2/3[2]

List of H-P inhibitors
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gollark: It actually seems like the whole setup handling them is deliberately byzantine and overcomplicated to stop this sort of thing.

References
  1. Wexler P, Anderson BD, eds. (2005). Encyclopedia of toxicology (2nd ed.). p. 1850. ISBN 978-0-08-054800-5.
  2. Thierry E, Brennich M, Round A, Buisson M, Burmeister WP, Hutin S (October 2015). "Production and characterisation of Epstein-Barr virus helicase-primase complex and its accessory protein BBLF2/3". Virus Genes. 51 (2): 171–81. doi:10.1007/s11262-015-1233-6. PMID 26292944.
  3. Kräusslich H, Bartenschlager R (2 December 2008). Antiviral Strategies. Springer Science & Business Media. pp. 162–8. ISBN 978-3-540-79086-0.
  4. Cavanaugh NA (2008). Herpes DNA Synthesis: Initiation of New DNA Strands and Discrimination Between Right and Wrong Bases by the Polymerase (Ph.D.). University of Colorado at Boulder. pp. 2–12. ISBN 978-0-549-67366-8.
  5. Kazlauskas D, Krupovic M, Venclovas Č (June 2016). "The logic of DNA replication in double-stranded DNA viruses: insights from global analysis of viral genomes". Nucleic Acids Research. 44 (10): 4551–64. doi:10.1093/nar/gkw322. PMC 4889955. PMID 27112572.
  6. Weller SK, Kuchta RD (October 2013). "The DNA helicase-primase complex as a target for herpes viral infection". Expert Opinion on Therapeutic Targets. 17 (10): 1119–32. doi:10.1517/14728222.2013.827663. PMC 4098783. PMID 23930666.
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