Hans Westerhoff

Hans Victor Westerhoff (born 14 January 1953 in Amsterdam)[1] is a Dutch biologist and biochemist who is professor of synthetic systems biology at the University of Amsterdam[4] and AstraZeneca professor of systems biology at the University of Manchester.[2] Currently he is a Chair of AstraZeneca and a director of the Manchester Centre for Integrative Systems Biology.[5][6]

Hans Westerhoff
Hans Westerhoff in 2014
Born
Hans Victor Westerhoff

(1953-01-14) 14 January 1953[1]
Alma materUniversity of Amsterdam (PhD)
Scientific career
FieldsSystems biology[2]
Institutions
ThesisMosaic non-equilibrium thermodynamics and (the control of) biological free-energy transduction (1983)
Academic advisorsKarel van Dam[1][3]
Websitewww.manchester.ac.uk/research/hans.westerhoff

Career

Westerhoff was educated at the University of Amsterdam where he was awarded a PhD in 1983 for investigations of non-equilibrium thermodynamics and the control of biological thermodynamics supervised by Karel van Dam.[1] In 1996 he succeeded Ad Stouthamer as professor of microbiology at the Vrije Universiteit Amsterdam.[7]

Research

In March 1995 Westerhoff wrote about a discovery of magainin in the African clawed frog which helps it fight against bacterias which he discovered along with his colleagues.[8] In December 1996 he and his group discovered a nitric-oxide reductase of Paracoccus denitrificans.[9] In 2000 he and Martin Bier, along with Barbara Bakker discovered that yeast cells can oscillate and merge with others in some cases because they get energized from glycolysis.[10][11] In 2013 he studied maps of human metabolism and came out with its biochemical map.[12]

gollark: Some episodes later... "We need X spare part for the spaceship!"
gollark: "Oh look let's just stick in this convenient FUTURE thing so our captain has coffee"
gollark: They never do consider the consequences of replicators, really.
gollark: I mean, it's onboard a military spaceship. They could just be getting imports of stuff they need.
gollark: How do you know *that*?

References
  1. Prof. dr. H.V. Westerhoff, 1953- at the University of Amsterdam Album Academicum website
  2. "Hans Westerhoff". Google Scholar. Archived from the original on December 18, 2013. Retrieved December 9, 2013.
  3. Academic Tree: Karel van Dam, Amsterdam
  4. "Prof. Dr. H.V. (Hans) Westerhoff". University of Amsterdam. Archived from the original on December 12, 2013. Retrieved December 9, 2013.
  5. "Professor Hans Westerhoff". University of Manchester. Archived from the original on December 15, 2013. Retrieved December 9, 2013.
  6. Hans Westerhoff's publications indexed by the Scopus bibliographic database. (subscription required)
  7. Martine Zuidweg (11 June 1997). "De confrontatie" (in Dutch). Trouw. Retrieved 19 July 2020.
  8. Westerhoff, H. V.; Zasloff, M.; Rosner, J. L.; Hendler, R. W.; Waal, A.; Gomes, A. V.; Jongsma, A. P. M.; Riethorst, A.; Juretic, D. (1995). "Functional Synergism of the Magainins PGLa and Magainin-2 in Escherichia coli, Tumor Cells and Liposomes" (PDF). European Journal of Biochemistry. 228 (2): 257–64. doi:10.1111/j.1432-1033.1995.0257n.x. PMID 7705337.
  9. Boer, A. P. N.; Oost, J.; Reijnders, W. N. M.; Westerhoff, H. V.; Stouthamer, A. H.; Spanning, R. J. M. (1996). "Mutational Analysis of the nor Gene Cluster which Encodes Nitric-Oxide Reductase from Paracoccus denitrificans". European Journal of Biochemistry. 242 (3): 592–600. doi:10.1111/j.1432-1033.1996.0592r.x. PMID 9022686.
  10. Bier, M; Bakker, B. M.; Westerhoff, H. V. (2000). "How yeast cells synchronize their glycolytic oscillations: A perturbation analytic treatment". Biophysical Journal. 78 (3): 1087–93. doi:10.1016/S0006-3495(00)76667-7. PMC 1300712. PMID 10692299.
  11. Herrgård, M. J.; Swainston, N.; Dobson, P.; Dunn, W. B.; Arga, K. Y. I.; Arvas, M.; Blüthgen, N.; Borger, S.; Costenoble, R.; Heinemann, M.; Hucka, M.; Le Novère, N.; Li, P.; Liebermeister, W.; Mo, M. L.; Oliveira, A. P.; Petranovic, D.; Pettifer, S.; Simeonidis, E.; Smallbone, K.; Spasić, I.; Weichart, D.; Brent, R.; Broomhead, D. S.; Westerhoff, H. V.; Kirdar, B. L.; Penttilä, M.; Klipp, E.; Palsson, B. Ø.; Sauer, U.; Oliver, S.G.; Mendes, P.; Nielsen, J.; Kell, D.B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology". Nature Biotechnology. 26 (10): 1155–1160. doi:10.1038/nbt1492. PMC 4018421. PMID 18846089.
  12. "Professor Westerhoff in study that maps human metabolism in health and disease". Amsterdam Institute of Molecules, Medicines and Systems. March 4, 2013. Archived from the original on October 6, 2014. Retrieved October 6, 2014.


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