HS1BP3

HCLS1 binding protein 3 also known as HS1BP3 is a protein which in humans is encoded by the HS1BP3 gene.[1][2]

HCLS1 binding protein 3
Identifiers
SymbolHS1BP3
NCBI gene64342
HGNC24979
OMIM609359
RefSeqNM_022460
UniProtQ53T59
Other data
LocusChr. 2 p24.1

Function

The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1-interacting protein that may be involved in lymphocyte activation.[3]

HS1BP3 binds members of the 14-3-3 protein family, which are highly expressed in motor neurons and Purkinje cells and regulate the Ca2+ / calmodulin-dependent protein kinase activation of tyrosine and tryptophan hydroxylase.[2]

gollark: Wait, no.
gollark: `journalctl -u unifi`
gollark: That looks like systemd, though. I'm sure there's a way to fetch a particular program's logs with that. If only I could remember it.
gollark: `sudo -i` and do whatever it is?
gollark: Racks are for putting multiple things in.

References
  1. Takemoto Y, Furuta M, Sato M, Kubo M, Hashimoto Y (December 1999). "Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3". Int. Immunol. 11 (12): 1957–64. doi:10.1093/intimm/11.12.1957. PMID 10590261.
  2. Higgins JJ, Lombardi RQ, Pucilowska J, Jankovic J, Tan EK, Rooney JP (February 2005). "A variant in the HS1-BP3 gene is associated with familial essential tremor". Neurology. 64 (3): 417–21. doi:10.1212/01.WNL.0000153481.30222.38. PMC 1201396. PMID 15699368.
  3. "Entrez Gene: HCLS1 binding protein 3".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.