HCLS1

HCLS1
Identifiers
Aliases	HCLS1, CTTNL, HS1, lckBP1, p75, hematopoietic cell-specific Lyn substrate 1
External IDs	OMIM: 601306 MGI: 104568 HomoloGene: 38034 GeneCards: HCLS1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	121,660,927 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	36,963,212 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• RNA polymerase II transcription factor binding; • SH3 domain binding; • GO:0001948 protein binding; • actin binding; • protein kinase binding; • GO:0032403 macromolecular complex binding;
Cellular component	• cytoplasm; • membrane; • transcription factor complex; • mitochondrion; • cell nucleus; • cytosol; • cell membrane;
Biological process	• positive regulation of protein kinase B signaling; • GO:0007243 intracellular signal transduction; • regulation of transcription, DNA-templated; • positive regulation of tyrosine phosphorylation of STAT protein; • positive regulation of macrophage differentiation; • negative regulation of transcription from RNA polymerase II promoter; • cellular response to cytokine stimulus; • positive regulation of peptidyl-serine phosphorylation; • regulation of actin filament polymerization; • actin filament polymerization; • positive regulation of cell proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of granulocyte differentiation; • erythrocyte differentiation; • negative regulation of leukocyte apoptotic process; • response to hormone; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of actin cytoskeleton reorganization; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of protein import into nucleus; • positive regulation of sequence-specific DNA binding transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	3059
	15163
	ENSG00000180353
	ENSMUSG00000022831
	P14317
	P49710
	NM_005335; NM_001292041
	NM_008225
	NP_001278970; NP_005326
	NP_032251
	Wikidata
View/Edit Human	View/Edit Mouse

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.[5][6][7]

Interactions

HCLS1 has been shown to interact with Caspase 3.[8][9]

gollark: The Chinese remainder theorem?

gollark: Immediately undergo exponentiation modulo 7, then.

gollark: I do not understand that sentence ("The alternative is work a political method for political reason.") and it is not pizza, I have had no commercial relations with pizza companies, I am not paid to subliminally advertise pizza, etc.

gollark: I guess maybe in politics/economics/sociology the alternative is something like "lean on human intuition" or "make the correct behaviour magically resolve from self-interest". Not sure how well those actually work.

gollark: - the replication crisis does exist, but it's not like *every paper* has a 50% chance of being wrong - it's mostly in some fields and you can generally estimate which things won't replicate fairly well without much specialized knowledge- science™ agrees on lots of things, just not some highly politicized things- you *can* do RCTs and correlation studies and such, which they seem to be ignoring- some objectivity is better than none- sure, much of pop science is not great, but that doesn't invalidate... all science- they complain about running things based on "trial and error and guesswork", but then don't offer any alternative

References

GRCh38: Ensembl release 89: ENSG00000180353 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022831 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 175–6. doi:10.1159/000134179. PMID 8978766.
van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics. 6: 15. doi:10.1186/1471-2164-6-15. PMC 554100. PMID 15710041.
"Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".
Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. England. 364 (Pt 1): 41–7. doi:10.1042/bj3640041. ISSN 0264-6021. PMC 1222543. PMID 11988074.
Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. United States. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.

Kitamura D, Kaneko H, Miyagoe Y, et al. (1990). "Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage". Nucleic Acids Res. 17 (22): 9367–79. PMC 335138. PMID 2587259.
Yamanashi Y, Okada M, Semba T, et al. (1993). "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3631–5. Bibcode:1993PNAS...90.3631Y. doi:10.1073/pnas.90.8.3631. PMC 46355. PMID 7682714.
Hata D, Nakamura T, Kawakami T, et al. (1994). "Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking". Immunol. Lett. 40 (1): 65–71. doi:10.1016/0165-2478(94)90208-9. PMID 7927516.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Egerton M, Moritz RL, Druker B, et al. (1996). "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes". Biochem. Biophys. Res. Commun. 224 (3): 666–74. doi:10.1006/bbrc.1996.1082. PMID 8713105.
Suzuki Y, Demoliere C, Kitamura D, et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases". J. Immunol. 158 (6): 2736–44. PMID 9058808.
Yamanashi Y, Fukuda T, Nishizumi H, et al. (1997). "Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis". J. Exp. Med. 185 (7): 1387–92. doi:10.1084/jem.185.7.1387. PMC 2196252. PMID 9104825.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Brunati AM, Donella-Deana A, James P, et al. (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase". J. Biol. Chem. 274 (11): 7557–64. doi:10.1074/jbc.274.11.7557. PMID 10066823.
Nagata Y, Kiefer F, Watanabe T, Todokoro K (1999). "Activation of hematopoietic progenitor kinase-1 by erythropoietin". Blood. 93 (10): 3347–54. PMID 10233887.
Takemoto Y, Furuta M, Sato M, et al. (2000). "Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3". Int. Immunol. 11 (12): 1957–64. doi:10.1093/intimm/11.12.1957. PMID 10590261.
Ruzzene M, Brunati AM, Sarno S, et al. (2000). "Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2". Eur. J. Biochem. 267 (10): 3065–72. doi:10.1046/j.1432-1033.2000.01333.x. PMID 10806407.
Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. PMID 11689006.
Ruzzene M, Penzo D, Pinna LA (2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. 364 (Pt 1): 41–7. doi:10.1042/bj3640041. PMC 1222543. PMID 11988074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
Uruno T, Zhang P, Liu J, et al. (2003). "Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization". Biochem. J. 371 (Pt 2): 485–93. doi:10.1042/BJ20021791. PMC 1223309. PMID 12534372.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180353 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022831 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978766-5] Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 175–6. doi:10.1159/000134179. PMID 8978766.

[pmid15710041-6] van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics. 6: 15. doi:10.1186/1471-2164-6-15. PMC 554100. PMID 15710041.

[entrez-7] "Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".

[pmid11988074-8] Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. England. 364 (Pt 1): 41–7. doi:10.1042/bj3640041. ISSN 0264-6021. PMC 1222543. PMID 11988074.

[pmid11689006-9] Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. United States. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.

HCLS1

Interactions

References

Further reading