HMG20B

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.[5][6]

HMG20B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRJ
Identifiers
Aliases	HMG20B, BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857, high mobility group 20B
External IDs	OMIM: 605535 MGI: 1341190 HomoloGene: 74949 GeneCards: HMG20B
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,572,777 bp[1] End 3,579,088 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 81,346,048 bp[2] End 81,350,480 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein heterodimerization activity • DNA binding • GO:0001948 protein binding • histone deacetylase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm • chromosome • nuclear body Biological process • skeletal muscle cell differentiation • cell cycle • negative regulation of protein sumoylation • blood coagulation • regulation of transcription, DNA-templated • positive regulation of neuron differentiation • transcription, DNA-templated • histone deacetylation • chromatin organization • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10362	15353
Ensembl	ENSG00000064961	ENSMUSG00000020232
UniProt	Q9P0W2	Q9Z104
RefSeq (mRNA)	NM_006339	NM_001163165 NM_001163166 NM_010440
RefSeq (protein)	NP_006330	NP_001156637 NP_001156638 NP_034570
Location (UCSC)	Chr 19: 3.57 – 3.58 Mb	Chr 10: 81.35 – 81.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

HMG20B has been shown to interact with:

• BRCA2,[7][8]
• HDAC1,[7]
• HDAC2,[7][9]
• KIF4A,[10]
• PHF21A,[7][11] and
• RCOR1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000064961 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020232 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sumoy L, Carim L, Escarceller M, Nadal M, Gratacòs M, Pujana MA, Estivill X, Peral B (Jun 2000). "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression". Cytogenetics and Cell Genetics. 88 (1–2): 62–7. doi:10.1159/000015486. PMID 10773667.
6. "Entrez Gene: HMG20B high-mobility group 20B".
7. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
8. Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. PMID 11207365.
9. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
10. Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
11. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

Further reading

• Wattler F, Wattler S, Kelly M, Skinner HB, Nehls M (September 1999). "Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family". Genomics. 60 (2): 172–8. doi:10.1006/geno.1999.5913. PMID 10486208.
• Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. PMID 11207365.
• Lee YM, Shin H, Choi W, Ahn S, Kim W (April 2002). "Characterization of human SMARCE1r high-mobility-group protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1574 (3): 269–76. doi:10.1016/s0167-4781(01)00373-6. PMID 11997092.
• Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (July 2002). "Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35". Biochemical and Biophysical Research Communications. 295 (1): 129–35. doi:10.1016/S0006-291X(02)00624-1. PMID 12083779.
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (July 2002). "Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens". Biochemical and Biophysical Research Communications. 295 (1): 136–41. doi:10.1016/S0006-291X(02)00625-3. PMID 12083780.
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
• Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
• Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• HMG20B human gene location in the UCSC Genome Browser.
• HMG20B human gene details in the UCSC Genome Browser.