HIV-2 retropepsin

HIV-2 retropepsin (EC 3.4.23.47) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Endopeptidase for which the P1 residue is preferably hydrophobic
HIV-2 retropepsin
Identifiers
EC number3.4.23.47
CAS number144114-21-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme belongs to the peptidase family A2.

References

  1. Tözsér J, Bláha I, Copeland TD, Wondrak EM, Oroszlan S (April 1991). "Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins". FEBS Letters. 281 (1–2): 77–80. doi:10.1016/0014-5793(91)80362-7. PMID 2015912.
  2. Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC (October 1994). "Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases". The Journal of Biological Chemistry. 269 (42): 26344–8. PMID 7929352.
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