Commiphora wightii

Commiphora wightii, with common names Indian bdellium-tree,[3] gugal,[4] guggul,[3] gugul,[3] or Mukul myrrh tree, is a flowering plant in the family Burseraceae, which produces a fragrant resin called gugal, guggul or gugul, that is used in incense and vedic medicine (or ayurveda). The guggul plant may be found from northern Africa to central Asia, but is most common in northern India. It prefers arid and semi-arid climates and is tolerant of poor soil.

Commiphora wightii

Critically Endangered  (IUCN 3.1)[1]
Scientific classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Sapindales
Family: Burseraceae
Genus: Commiphora
Species:
C. wightii
Binomial name
Commiphora wightii
(Arn.) Bhandari
Synonyms[2]
  • Commiphora mukul (Stocks) Hook.
  • Commiphora roxburghii (Stocks) Engl.
Commiphora wightii resin (guggul)

Description

Commiphora wightii grows as a shrub or small tree, reaching a maximum height of 4 m (13 ft), with thin papery bark.[4] The branches are thorny. The leaves are simple or trifoliate, the leaflets ovate, 1–5 cm (0.39–1.97 in) long, 0.5–2.5 cm (0.20–0.98 in) broad, and irregularly toothed. It is gynodioecious, with some plants bearing bisexual and male flowers, and others with female flowers. The individual flowers are red to pink, with four small petals. The small round fruit are red when ripe.

Cultivation and uses

Commiphora wightii is sought for its gummy resin, which is harvested from the plant's bark through the process of tapping. In India and Pakistan, guggul is cultivated commercially. The resin of C. wightii, known as gum guggulu, has a fragrance similar to that of myrrh and is commonly used in incense and perfumes. It is the same product that was known in Hebrew, ancient Greek and Latin sources as bdellium.

Guggul is used in Ayurveda remedies and it is mentioned in Ayurvedic texts dating back to 600 BC. [5] It is often sold as a herbal supplement.

The gum can be purchased in a loosely packed form called dhoop, an incense from India, which is burned over hot coals. This produces a fragrant, dense smoke. [6] It is also sold in the form of incense sticks and dhoop cones which can be burned directly.

Chemical composition

Over a hundred metabolites of various chemical compositions were reported from the leaves, stem, latex, root and fruit samples. High concentrations of quinic acid and myo-inositol were found in fruits and leaves.[7]

Traditional medicinal use

Commiphora wightii has been a key component in ancient Indian Ayurvedic system of medicine.

Chemical structure of guggulsterone, a constituent of gum guggul

The extract of gum guggul, called gugulipid, guggulipid, or guglipid, has been used in Unani and Ayurvedic medicine, for nearly 3,000 years in India.[8][9] One chemical ingredient in the extract is the steroid guggulsterone,[10] which acts as an antagonist of the farnesoid X receptor, once believed to result in decreased cholesterol synthesis in the liver. However, several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone and levels of low-density lipoprotein ("bad cholesterol") increased in many people.[11][12]

Endangerment and rescue
'Save Guggul Movement' in Rajasthan, India

Because of its use in traditional medicine, C. wightii has been overharvested, and has become so scarce in its two habitats in India—Gujarat and Rajasthan—that the World Conservation Union (IUCN) has enlisted it in its IUCN Red List of threatened species.[1] Several efforts are in place to address this situation. India's National Medicinal Plants Board launched a project in Kutch District to cultivate 500 to 800 hectares (1,200 to 2,000 acres) of guggal,[13] while a grass-roots conservation movement, led by IUCN associate Vineet Soni, has been started to educate guggal growers and harvesters in safe, sustainable harvesting methods.[14][15]

gollark: I suppose the best ways to get around that would be to... either specify a power which is small and not very useful so they won't meddle with it much, specify one which *seems* small and non-useful but isn't, rigorously and precisely specify a useful one, or just get some sort of ridiculously meta power.
gollark: Why would the person before you make there be a side effect? Just being spiteful and annoying?
gollark: You can actually run it in one of the many CC emulators which run out of the game, too, and this is where I do much of the testing.
gollark: Also it's entirely stored on pastebin and has no version control and is split across probably 15 different files.
gollark: I added a thing where I can remote into potatOS computers for... definitely debugging purposes... and run code, which makes it much easier to patch sandbox escapes where silly triangles don't release the code.

References
  1. Ved, D.; Saha, D.; Ravikumar, K.; Haridasan, K. (2015). "Commiphora wightii-Guggul". IUCN Red List of Threatened Species. 2015: e.T31231A50131117. doi:10.2305/IUCN.UK.2015-2.RLTS.T31231A50131117.en.
  2. "Tropicos.org". Archived from the original on 3 March 2016. Retrieved 6 June 2014.
  3. "Commiphora wightii". Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States Department of Agriculture (USDA). Retrieved 13 September 2014.
  4. Sultanul Abedin & S.I. Ali. "Commiphora wightii". Flora of Pakistan. 26.
  5. "Guggul: Uses, Side Effects, Interactions, Dosage, and Warning". Web MD.
  6. "Guggul (Indian Bedellium)".
  7. Bhatia, Anil; Bharti, Santosh K.; Tripathi, Tusha; Mishra, Anuradha; Sidhu, Om P.; Roy, Raja; Nautiyal, Chandra Shekhar (1 February 2015). "Metabolic profiling of Commiphora wightii (guggul) reveals a potential source for pharmaceuticals and nutraceuticals". Phytochemistry. 110: 29–36. doi:10.1016/j.phytochem.2014.12.016. PMID 25561401.
  8. Indian herb can reduce cholesterol Archived 2008-02-03 at the Wayback Machine, BBC NEWS, 2 May 2002
  9. Mohan, Mohind C.; Abhimannue, Anu P.; Kumar, B.Prakash (January 2019). "Modulation of proinflammatory cytokines and enzymes by polyherbal formulation Guggulutiktaka ghritam". Journal of Ayurveda and Integrative Medicine. doi:10.1016/j.jaim.2018.05.007. PMID 30638916.
  10. Murray (2012). Joseph E. Pizzorno Jr.; Michael T. (eds.). Textbook of natural medicine (4th ed.). Edinburgh: Churchill Livingstone. p. 691. ISBN 9781437723335.
  11. Szapary, PO; Wolfe, ML; Bloedon, LT; Cucchiara, AJ; Dermarderosian, AH; Cirigliano, MD; Rader, DJ (2003). "Guggulipid Ineffective for Lowering Cholesterol". JAMA. 290 (6): 765–772. doi:10.1001/jama.290.6.765. PMID 12915429.
  12. Sahni, S; Hepfinger, CA; Sauer, KA (2005). "Guggulipid Use in Hyperlipidemia". Am J Health-Syst Pharm. 62 (16): 1690–1692. doi:10.2146/ajhp040580. PMID 16085931.
  13. Maheshwari, D V (8 January 2008). "Kutch to house Centre's Rs 8-cr Guggal conservation project". The Indian Express. Archived from the original on 9 October 2008. Retrieved 9 January 2008.
  14. Paliwal, Ankur (31 July 2010). "Guggal faces sticky end". Down to Earth: Science and Environment Online. Archived from the original on 10 January 2012. Retrieved 12 January 2012.
  15. "Education and Awareness in the 'Save Guggul Movement'". IUCN News. 31 July 2010. Archived from the original on 21 December 2011. Retrieved 12 January 2012.
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