Glassy cell carcinoma of the cervix

Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix.[1] The tumour gets its name from its microscopic appearance; its cytoplasm has a glass-like appearance.

Glassy cell carcinoma of the cervix
Micrograph of a glassy cell carcinoma of the cervix. H&E stain.
SpecialtyOncology 

Signs and symptoms

The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.

Cause

Diagnosis

The diagnosis is based on tissue examination, e.g. biopsy.

Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated with an inflammatory infiltrate abundant in eosinophils and very mitotically active. PAS staining highlights the plasma membrane.[2]

Treatment

The treatment is dependent on the stage. Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and chemotherapy.[2]

gollark: 2G prizes? I REALLY should have gotten two.
gollark: Well, they're generally spread out more.
gollark: Why would there be a release in just a week?
gollark: Probably should have gotten two while they existed.
gollark: At least I managed to grab one of the current ones before they went away.

See also

Additional images
  • Low mag.
  • High mag.

References
  1. Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix". J Obstet Gynaecol Res. 35 (3): 584–7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406.
  2. Deshpande, AH.; Kotwal, MN.; Bobhate, SK. "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature". Indian J Cancer. 41 (2): 92–5. PMID 15318016.

Further reading
  • Greer, Benjamin E.; Koh, Wui-Jin; Abu-Rustum, Nadeem; Bookman, Michael A.; Bristow, Robert E.; Campos, Susana M.; Cho, Kathleen R.; Copeland, Larry; Crispens, Marta Ann; Eifel, Patricia J.; Huh, Warner K.; Jaggernauth, Wainwright; Kapp, Daniel S.; Kavanagh, John J.; Lurain, John R.; Morgan, Mark; Morgan, Robert J.; Powell, C. Bethan; Remmenga, Steven W.; Reynolds, R. Kevin; Secord, Angeles Alvarez; Small, William; Teng, Nelson (1 May 2009). "Uterine Neoplasms". Journal of the National Comprehensive Cancer Network. 7 (5): 498–531. doi:10.6004/jnccn.2009.0035. ISSN 1540-1405. Retrieved 19 July 2017.
Classification
  • ICD-10: C53.0 C53.1 C53.8
External resources
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