Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (EC 4.3.2.6, btrG (gene)) is an enzyme with systematic name gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (5-oxoproline producing).[1] This enzyme catalyses the following chemical reaction

gamma-L-glutamyl-butirosin B butirosin B + 5-oxoproline
Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
Identifiers
EC number4.3.2.6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B.

References

  1. Llewellyn NM, Li Y, Spencer JB (April 2007). "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain". Chemistry & Biology. 14 (4): 379–86. doi:10.1016/j.chembiol.2007.02.005. PMID 17462573.
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