GRAM domain-containing 2B

GRAM domain-containing 2B protein (GRAMD2B; formerly GRAMD3), also known as NS3TP2 and HCV NS3-transactivated protein 2 is a protein encoded by the GRAMD2B gene.[5][6]

GRAMD2B
Identifiers
AliasesGRAMD2B, NS3TP2, GRAMD3, GRAM domain containing 3, GRAM domain containing 2B
External IDsMGI: 1914815 HomoloGene: 32570 GeneCards: GRAMD2B
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q23.2Start126,360,132 bp[1]
End126,496,494 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

65983

107022

Ensembl

ENSG00000155324

ENSMUSG00000001700

UniProt

Q96HH9

Q6PEM6

RefSeq (mRNA)

NM_026240
NM_001360917

RefSeq (protein)

NP_080516
NP_001347846

Location (UCSC)Chr 5: 126.36 – 126.5 MbChr 18: 56.4 – 56.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRAMD2B has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2A. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.[7]

GRAMD2B consists of a GRAM domain and a transmembrane domain anchoring it to the endoplasmic reticulum.[8][7] Similar to GRAMD2A, GRAMD2B lacks the VASt domain found in LAM and GRAMD1 proteins. Its function has not yet been defined, but is likely similar to that of GRAMD2A.

References

  1. GRCh38: Ensembl release 89: ENSG00000155324 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001700 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]". Retrieved March 7, 2020.
  6. "UniProtKB - Q96HH9 (GRM2B_HUMAN)". Retrieved March 7, 2020.
  7. Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.
  8. "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.
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