GGL domain
GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.[1]
 Phosducin - transducin beta-gamma complex. Gamma subunit (GGL domain) colored red. | |||||||||||
| Identifiers | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbol | G-gamma | ||||||||||
| Pfam | PF00631 | ||||||||||
| InterPro | IPR001770 | ||||||||||
| SMART | GGL | ||||||||||
| PROSITE | PDOC01002 | ||||||||||
| SCOPe | 1gp2 / SUPFAM | ||||||||||
| OPM protein | 2bcj | ||||||||||
| CDD | cd00068 | ||||||||||
| |||||||||||
Human proteins containing this domain
gollark: ```Shulkers spawn during generation of end cities, which are located on the outer islands of the End. They usually spawn on the walls of the city. They don't despawn naturally, even in Peaceful difficulty, and once killed, they don't respawn.```https://minecraft.gamepedia.com/ShulkerWe can't blame CLNinja5cn for *every* scarcity issue.
gollark: *checks wi'iki*
gollark: Wait, shulkers are refilled by the dragon being spawned?
gollark: No they won't.
gollark: GUIs tend to be.
See also
- Beta-gamma complex
References
- Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (1998). "A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13307–12. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
Further reading
- Chatterjee TK, Liu Z, Fisher RA (August 2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". J. Biol. Chem. 278 (32): 30261–71. doi:10.1074/jbc.M212687200. PMID 12761221.
- Chen CK, Eversole-Cire P, Zhang H, et al. (May 2003). "Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6604–9. doi:10.1073/pnas.0631825100. PMC 164494. PMID 12738888.
- Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
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