GCS1

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.[5][6][7]

MOGS
Identifiers
AliasesMOGS, CDG2B, CWH41, DER7, GCS1, mannosyl-oligosaccharide glucosidase
External IDsOMIM: 601336 MGI: 1929872 HomoloGene: 4593 GeneCards: MOGS
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.1Start74,461,057 bp[1]
End74,465,410 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7841

57377

Ensembl

ENSG00000115275

ENSMUSG00000030036

UniProt

Q13724

Q80UM7

RefSeq (mRNA)

NM_006302
NM_001146158

NM_020619

RefSeq (protein)

NP_001139630
NP_006293

NP_065644

Location (UCSC)Chr 2: 74.46 – 74.47 MbChr 6: 83.12 – 83.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.[7]

GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible for gametes fusion .[8] .

References

  1. GRCh38: Ensembl release 89: ENSG00000115275 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030036 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kalz-Fuller B, Bieberich E, Bause E (Sep 1995). "Sexualization and expression of glucosidase I from human hippocampus". Eur J Biochem. 231 (2): 344–51. doi:10.1111/j.1432-1033.1995.tb20706.x. PMID 7635146.
  6. Kalz-Fuller B, Heidrich-Kaul C, Nothen M, Bause E, Schwanitz G (Sep 1996). "Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics. 34 (3): 442–3. doi:10.1006/geno.1996.0313. PMID 8786151.
  7. "Entrez Gene: GCS1 glucosidase I".
  8. Goodman CD, McFadden GI (2008). "Gamete Fusion: Key Protein Identified". Current Biology. 18 (13): R571–R573. doi:10.1016/j.cub.2008.05.007. Retrieved 06.05.09. Check date values in: |accessdate= (help)

Further reading


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