Flutrimazole
Flutrimazole is a wide-spectrum antifungal drug. It is used for the topical treatment of superficial mycoses of the skin. Flutrimazole is an imidazole derivative. Its antifungal activity has been demonstrated in in vivo and in vitro studies to be comparable to that of clotrimazole and higher than bifonazole.[1]
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| ECHA InfoCard | 100.170.770  |
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| Formula | C22H16F2N2 |
| Molar mass | 346.381 g·mol−1 |
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| Chirality | Racemic mixture |
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Mechanism of action
It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol 14 α-demethylase.
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See also
References
The Merck Index, 12th Edition. 4247
- Alomar A, Videla S, Delgadillo J, Gich I, Izquierdo I, Forn J (1995). "Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1% cream. Efficacy of flutrimazole 1% dermal cream in dermatomycoses. Catalan Flutrimazole Study Group". Dermatology. 190 (4): 295–300. doi:10.1159/000246720. PMID 7655109.
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