FLRT3

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.[5][6]

FLRT3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFLRT3, HH21, fibronectin leucine rich transmembrane protein 3
External IDsOMIM: 604808 MGI: 1918686 HomoloGene: 8322 GeneCards: FLRT3
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20p12.1Start14,322,985 bp[1]
End14,337,614 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23767

71436

Ensembl

ENSG00000125848

ENSMUSG00000051379

UniProt

Q9NZU0

Q8BGT1

RefSeq (mRNA)

NM_013281
NM_198391

NM_001172160
NM_178382

RefSeq (protein)

NP_037413
NP_938205

NP_001165631
NP_848469

Location (UCSC)Chr 20: 14.32 – 14.34 MbChr 2: 140.65 – 140.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000125848 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051379 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lacy SE, Bonnemann CG, Buzney EA, Kunkel LM (Mar 2000). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics. 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.
  6. "Entrez Gene: FLRT3 fibronectin leucine rich transmembrane protein 3".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.