FLRT1

FLRT1
Identifiers
Aliases	FLRT1, SPG68, fibronectin leucine rich transmembrane protein 1
External IDs	OMIM: 604806 MGI: 3026647 HomoloGene: 40864 GeneCards: FLRT1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	64,119,173 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	7,105,729 bp[2]
Gene ontology
Molecular function	• protein binding, bridging; • fibroblast growth factor receptor binding; • protein kinase inhibitor activity;
Cellular component	• cytoplasm; • integral component of membrane; • cell projection; • endoplasmic reticulum membrane; • membrane; • intercellular junction; • focal adhesion; • integral component of plasma membrane; • neuronal cell body membrane; • extracellular region; • cell junction; • endoplasmic reticulum; • perinuclear region of cytoplasm; • neuron projection terminus; • cytoplasmic vesicle membrane; • cytoplasmic vesicle; • cell membrane; • extracellular; • extracellular matrix;
Biological process	• negative regulation of protein kinase activity; • cytokine-mediated signaling pathway; • dendrite development; • neuron projection extension; • multicellular organism development; • cell adhesion; • negative regulation of JAK-STAT cascade; • positive regulation of synapse assembly; • fibroblast growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23769
	396184
	ENSG00000126500
	ENSMUSG00000047787
	Q9NZU1
	Q6RKD8
	NM_013280
	NM_201411
	NP_037412
	NP_958813
	Wikidata
View/Edit Human	View/Edit Mouse

Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. [5]

Function

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in the kidney and brain.

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References

GRCh38: Ensembl release 89: ENSG00000126500 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047787 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Fibronectin leucine rich transmembrane protein 1". Retrieved 2017-05-30.

FLRT1

Function

References

Further reading