Epstein–Barr virus nuclear antigen 3

The Epstein–Barr virus nuclear antigen 3 (EBNA-3) is a family of viral proteins associated with the Epstein–Barr virus. A typical EBV genome contains three such proteins:[1]

  • EBNA-3A (P12977, EBNA-3; BLRF3-BERF1)
  • EBNA-3B (P03203, EBNA-4; BERF2A-BERF2B)
  • EBNA-3C (P03204, EBNA-6, EBNA-4B; BERF3-BERF4)
Epstein–Barr virus nuclear antigen 3
Identifiers
SymbolEBV-NA3
PfamPF05009
InterProIPR007706
SCOPe1m05 / SUPFAM

These genes also bind the host RBP-Jκ protein.[2]

EBNA-3C can recruit a ubiquitin ligase and has been shown to target cell-cycle regulators such as retinoblastoma protein (pRb).[3][4]

References
  1. Jiang, H; Cho, YG; Wang, F (July 2000). "Structural, functional, and genetic comparisons of Epstein-Barr virus nuclear antigen 3A, 3B, and 3C homologues encoded by the rhesus lymphocryptovirus". Journal of Virology. 74 (13): 5921–32. doi:10.1128/jvi.74.13.5921-5932.2000. PMID 10846073.
  2. Kalchschmidt, JS; Gillman, AC; Paschos, K; Bazot, Q; Kempkes, B; Allday, MJ (January 2016). "EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells". PLOS Pathogens. 12 (1): e1005383. doi:10.1371/journal.ppat.1005383. PMID 26751214.
  3. Knight JS, Sharma N, Robertson ES (2005). "SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen". Mol. Cell. Biol. 25 (5): 1749–63. doi:10.1128/MCB.25.5.1749-1763.2005. PMC 549383. PMID 15713632.
  4. Knight JS, Sharma N, Robertson ES (2005). "Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18562–6. Bibcode:2005PNAS..10218562K. doi:10.1073/pnas.0503886102. PMC 1317900. PMID 16352731.


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