Dioscorea composita

Dioscorea composita, or barbasco, is a species of yam in the genus Dioscorea, native to Mexico. It is notable for its role in the production of diosgenin, which is a precursor for the synthesis of hormones such as progesterone.[1] Russell Marker developed the extraction and manufacture of hormones from D. mexicana at Syntex, starting the trade of D. composita in Mexico. Marker also discovered that the composita variety had a much higher content of diosgenin than the mexicana variety, and therefore it came to replace the latter in the production of synthetic hormones.[2]

Dioscorea composita
Scientific classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Monocots
Order: Dioscoreales
Family: Dioscoreaceae
Genus: Dioscorea
Species:
D. composita
Binomial name
Dioscorea composita

Chemical constituents

Steroidal sapogenin, diosgenin.[3]

Medicinal use

It is a source of diosgenin, which is used to prepare synthetic hormones such as progesterone and cortisone. Diosgenin extracted from Dioscorea composita was instrumental in the development of the combined oral contraceptive pill in the 1960s – and also for the development of cortisone treatments of arthritis. Studies on Diosgenin say that it has effect on diabetic neuropathy.[4]

Before becoming used industrially the tuber was used by Chinantec healers in northern Oaxaca as an abortifacient and in cures for aching joints. It was also used by chinantecs as a poison for fishing in the Papaloapan river, and is also mentioned in use for this purpose in the Popol Vuh, the sacred book of the K'iche maya.[5]

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References
  1. "Dioscorea composita". Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States Department of Agriculture (USDA). Retrieved 21 January 2018.
  2. "Archived copy". Archived from the original on 2010-09-25. Retrieved 2012-04-30.CS1 maint: archived copy as title (link)
  3. Indian herbal pharmacopia Vol.II.
  4. Biol Pharm Bull. 2011;34(9):1493-8.Kang TH, Moon E, Hong BN, Choi SZ, Son M, Park JH, Kim SY.
  5. Soto Laveaga, Gabriela (2009). Jungle Laboratories: MExican peasants, National Projects and the Making of the Pill. Duke University. pp. 72–73.
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