Dicyclohexylurea

Dicyclohexylurea
Names
	IUPAC name 1,3-dicyclohexylurea
	Other names DCU
Identifiers
CAS Number	2387-23-7 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1458 ;
ChemSpider	4126 ;
ECHA InfoCard	100.017.468
EC Number	219-213-7;
PubChem CID	4277;
UNII	ZV7823VVIM ;
CompTox Dashboard (EPA)	DTXSID3062366 ;
	InChI InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16) Key: ADFXKUOMJKEIND-UHFFFAOYSA-N ; InChI=1/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16) Key: ADFXKUOMJKEIND-UHFFFAOYAR; InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16) Key: ADFXKUOMJKEIND-UHFFFAOYSA-N;
	SMILES O=C(NC1CCCCC1)NC2CCCCC2;
Properties
Chemical formula	C13H24N2O
Molar mass	224.348 g·mol−1
Melting point	230 to 233 °C (446 to 451 °F; 503 to 506 K)
Hazards
Safety data sheet	External MSDS
GHS pictograms
GHS Signal word	Warning
GHS hazard statements	H302
GHS precautionary statements	P264, P270, P301+312, P330, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

Dicyclohexylurea is an organic compound, specifically, a urea. It is the byproduct of the reaction of dicyclohexylcarbodiimide with amines or alcohols. It may be prepared by the reaction of cyclohexylamine and S,S-dimethyl dithiocarbonate.[1] 1,3-Dicyclohexyl urea (DCU) is a potent soluble epoxide hydrolase (sEH) inhibitor. It has been shown to lower systemic blood pressure by 22 ± 4 mmHg in SHR.[2]

References

Man-kit Leung; Jun-Liang Lai; King-Hang Lau; Hsiao-hua Yu; Hsiang-Ju Hsiao (1996). "S,S-Dimethyl Dithiocarbonate: A Convenient Reagent for the Synthesis of Symmetrical and Unsymmetrical Ureas". The Journal of Organic Chemistry. 61 (12): 4175–4179. doi:10.1021/jo9522825. PMID 11667305.
Sarbani Ghosh, Po-Chang Chiang, Jan L. Wahlstrom, Hideji Fujiwara, Jon G. Selbo andSteven L. Roberds (2008). "Oral Delivery of 1,3-Dicyclohexylurea Nanosuspension Enhances Exposure and Lowers Blood Pressure in Hypertensive Rats". Basic & Clinical Pharmacology & Toxicology. 102 (5): 453–458. doi:10.1111/j.1742-7843.2008.00213.x.CS1 maint: multiple names: authors list (link)

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[1] Man-kit Leung; Jun-Liang Lai; King-Hang Lau; Hsiao-hua Yu; Hsiang-Ju Hsiao (1996). "S,S-Dimethyl Dithiocarbonate: A Convenient Reagent for the Synthesis of Symmetrical and Unsymmetrical Ureas". The Journal of Organic Chemistry. 61 (12): 4175–4179. doi:10.1021/jo9522825. PMID 11667305.

[2] Sarbani Ghosh, Po-Chang Chiang, Jan L. Wahlstrom, Hideji Fujiwara, Jon G. Selbo andSteven L. Roberds (2008). "Oral Delivery of 1,3-Dicyclohexylurea Nanosuspension Enhances Exposure and Lowers Blood Pressure in Hypertensive Rats". Basic & Clinical Pharmacology & Toxicology. 102 (5): 453–458. doi:10.1111/j.1742-7843.2008.00213.x.CS1 maint: multiple names: authors list (link)