Debrisoquine

Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a drug-metabolizing enzyme.[2]

Debrisoquine[1]

Names
IUPAC name 1,2,3,4-tetrahydroisoquinoline-2-carboximidamide
Identifiers
CAS Number	1131-64-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:34665^Y
ChEMBL	ChEMBL169901^Y
ChemSpider	2860^Y
DrugBank	DB04840^Y
ECHA InfoCard	100.013.155
KEGG	C13650^Y
MeSH	Debrisoquine
PubChem CID	2966
UNII	X31CDK040E^Y
CompTox Dashboard (EPA)	DTXSID7022885
InChI InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)^Y Key: JWPGJSVJDAJRLW-UHFFFAOYSA-N^Y InChI=1/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12) Key: JWPGJSVJDAJRLW-UHFFFAOYAE
SMILES [N@H]=C(N)N2Cc1c(cccc1)CC2
Properties
Chemical formula	C10H13N3
Molar mass	175.23032
Pharmacology
ATC code	C02CC04 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

See also

• Isoquinoline#Applications of derivatives

The guanidine part of the molecule also appears in guanoxan and guanadrel.

• The 7-bromo analog of Debrisoquine is called Guanisoquin.

References

1. Debrisoquine – Compound Summary, PubChem.
2. Fuhr, U.; Jetter, A.; Kirchheiner, J. (2007). "Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the "Cocktail" Approach". Clinical Pharmacology & Therapeutics. 81 (2): 270–283. doi:10.1038/sj.clpt.6100050.