Deacetylipecoside synthase

In enzymology, a deacetylipecoside synthase (EC 4.3.3.4) is an enzyme that catalyzes the chemical reaction

deacetylipecoside + H2O dopamine + secologanin
deacetylipecoside synthase
Identifiers
EC number4.3.3.4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are deacetylipecoside and H2O, whereas its two products are dopamine and secologanin.

This enzyme belongs to the family of lyases, specifically amine lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is deacetylipecoside dopamine-lyase (secologanin-forming). This enzyme is also called deacetylipecoside dopamine-lyase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

References

    • De-Eknamkul W, Ounaroon A, Tanahashi T, Kutchan TM, Zenk MH (1997). "Enzymatic condensation of dopamine and secologanin by cell-free extracts of Alangium lamarckii". Phytochemistry. 45 (3): 477–484. doi:10.1016/S0031-9422(96)00828-X.


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