DPYSL2

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.[5][6]

DPYSL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GSE, 2VM8
Identifiers
Aliases	DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, dihydropyrimidinase like 2
External IDs	OMIM: 602463 MGI: 1349763 HomoloGene: 74392 GeneCards: DPYSL2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 26,514,031 bp[1] End 26,658,178 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 34.6 cM Start 66,802,864 bp[2] End 66,868,688 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • microtubule binding • dihydropyrimidinase activity • GO:0001948 protein binding • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds • hydrolase activity • identical protein binding Cellular component • cytoplasm • cytosol • membrane • extracellular exosome • microtubule • cytoskeleton • cell membrane Biological process • regulation of neuron differentiation • cell differentiation • endocytosis • regulation of axon extension • nervous system development • multicellular organism development • brain development • cytoskeleton organization • nucleobase-containing compound metabolic process • signal transduction • axon guidance • pyrimidine nucleobase catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1808	12934
Ensembl	ENSG00000092964	ENSMUSG00000022048
UniProt	Q16555	O08553
RefSeq (mRNA)	NM_001386 NM_001197293 NM_001244604	NM_009955 NM_001378767
RefSeq (protein)	NP_001184222 NP_001231533 NP_001377	NP_034085 NP_001365696
Location (UCSC)	Chr 8: 26.51 – 26.66 Mb	Chr 14: 66.8 – 66.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

DPYSL2 has been shown to interact with CRMP1,[7] Adaptor-related protein complex 2, alpha 1[8] and NUMB.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000092964 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022048 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
6. "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".
7. Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. Netherlands. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.
8. Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. England. 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM (1995). "Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33". Nature. 376 (6540): 509–14. Bibcode:1995Natur.376..509G. doi:10.1038/376509a0. PMID 7637782.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Roberts RG, Freeman TC, Kendall E, et al. (1996). "Characterization of DRP2, a novel human dystrophin homologue". Nat. Genet. 13 (2): 223–6. doi:10.1038/ng0696-223. PMID 8640231.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kitamura K, Takayama M, Hamajima N, et al. (2000). "Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene". DNA Res. 6 (5): 291–7. doi:10.1093/dnares/6.5.291. PMID 10574455.
• Gu Y, Hamajima N, Ihara Y (2000). "Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522". Biochemistry. 39 (15): 4267–75. doi:10.1021/bi992323h. PMID 10757975.
• Gu Y, Ihara Y (2000). "Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules". J. Biol. Chem. 275 (24): 17917–20. doi:10.1074/jbc.C000179200. PMID 10770920.
• Arimura N, Inagaki N, Chihara K, et al. (2000). "Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse". J. Biol. Chem. 275 (31): 23973–80. doi:10.1074/jbc.M001032200. PMID 10818093.
• Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
• Santolini E, Puri C, Salcini AE, et al. (2001). "Numb Is an Endocytic Protein". J. Cell Biol. 151 (6): 1345–52. doi:10.1083/jcb.151.6.1345. PMC 2190585. PMID 11121447.
• Lee S, Kim JH, Lee CS, et al. (2002). "Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction". J. Biol. Chem. 277 (8): 6542–9. doi:10.1074/jbc.M108047200. PMID 11741937.
• Weitzdoerfer R, Fountoulakis M, Lubec G (2002). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain". J. Neural Transm. Suppl. (61): 95–107. doi:10.1007/978-3-7091-6262-0_8. ISBN 978-3-211-83704-7. PMID 11771764.
• Fukata Y, Itoh TJ, Kimura T, et al. (2002). "CRMP-2 binds to tubulin heterodimers to promote microtubule assembly". Nat. Cell Biol. 4 (8): 583–91. doi:10.1038/ncb825. PMID 12134159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Leung T, Ng Y, Cheong A, et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. PMID 12482610.
• Nishimura T, Fukata Y, Kato K, et al. (2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9): 819–26. doi:10.1038/ncb1039. PMID 12942088.
• Nakata K, Ujike H, Tanaka Y, et al. (2003). "No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans". Neurosci. Lett. 349 (3): 171–4. doi:10.1016/S0304-3940(03)00824-3. PMID 12951196.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.