CRMP1

Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.[5]

CRMP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B3Z
Identifiers
Aliases	CRMP1, CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3, collapsin response mediator protein 1
External IDs	OMIM: 602462 MGI: 107793 HomoloGene: 20347 GeneCards: CRMP1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.2 Start 5,748,084 bp[1] End 5,893,086 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B3|5 19.96 cM Start 37,241,940 bp[2] End 37,292,133 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • hydrolase activity • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds • filamin binding Cellular component • spindle • cytoskeleton • microtubule organizing center • cytoplasm • cytosol • midbody • centrosome • cell nucleus Biological process • neuron development • nucleobase-containing compound metabolic process • microtubule cytoskeleton organization • nervous system development • axon guidance • negative regulation of actin filament binding • negative regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1400	12933
Ensembl	ENSG00000072832	ENSMUSG00000029121
UniProt	Q14194	P97427
RefSeq (mRNA)	NM_001313 NM_001014809 NM_001288661 NM_001288662	NM_001136058 NM_007765
RefSeq (protein)	NP_001014809 NP_001275590 NP_001275591 NP_001304	NP_001129530 NP_031791
Location (UCSC)	Chr 4: 5.75 – 5.89 Mb	Chr 5: 37.24 – 37.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.[5]

CRMP1 mediates reelin signaling in cortical neuronal migration.[6] Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory.[7]

CRMP1 gene overlaps with another gene called EVC.[8]

Interactions

CRMP1 has been shown to interact with DPYSL2.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000072832 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029121 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CRMP1 collapsin response mediator protein 1".
6. Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y (December 2006). "Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration". J. Neurosci. 26 (51): 13357–62. doi:10.1523/JNEUROSCI.4276-06.2006. PMID 17182786.
7. Su KY, Chien WL, Fu WM, Yu IS, Huang HP, Huang PH, Lin SR, Shih JY, Lin YL, Hsueh YP, Yang PC, Lin SW (March 2007). "Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory". J. Neurosci. 27 (10): 2513–24. doi:10.1523/JNEUROSCI.4497-06.2007. PMID 17344389.
8. Ruiz-Perez VL, Ide SE, Strom TM, Lorenz B, Wilson D, Woods K, King L, Francomano C, Freisinger P, Spranger S, Marino B, Dallapiccola B, Wright M, Meitinger T, Polymeropoulos MH, Goodship J (March 2000). "Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis". Nat. Genet. 24 (3): 283–6. doi:10.1038/73508. PMID 10700184.
9. Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.

External links

• Human CRMP1 genome location and CRMP1 gene details page in the UCSC Genome Browser.

Further reading

• Shih JY, Lee YC, Yang SC, et al. (2003). "Collapsin response mediator protein-1: a novel invasion-suppressor gene". Clin. Exp. Metastasis. 20 (1): 69–76. doi:10.1023/A:1022598604565. PMID 12650609.
• Hamajima N, Matsuda K, Sakata S, et al. (1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
• Torres R, Polymeropoulos MH (1999). "Genomic organization and localization of the human CRMP-1 gene". DNA Res. 5 (6): 393–5. doi:10.1093/dnares/5.6.393. PMID 10048489.
• Shih JY, Yang SC, Hong TM, et al. (2001). "Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells". J. Natl. Cancer Inst. 93 (18): 1392–400. doi:10.1093/jnci/93.18.1392. PMID 11562390.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Leung T, Ng Y, Cheong A, et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. PMID 12482610.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Chang CC, Shih JY, Jeng YM, et al. (2004). "Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis". J. Natl. Cancer Inst. 96 (5): 364–75. doi:10.1093/jnci/djh059. PMID 14996858.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sivakumaran TA, Lesperance MM (2005). "Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes". Int. J. Mol. Med. 14 (5): 903–7. doi:10.3892/ijmm.14.5.903. PMID 15492864.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Cole AR, Causeret F, Yadirgi G, et al. (2006). "Distinct Priming Kinases Contribute to Differential Regulation of Collapsin Response Mediator Proteins by Glycogen Synthase Kinase-3 in Vivo". J. Biol. Chem. 281 (24): 16591–8. doi:10.1074/jbc.M513344200. PMC 1805471. PMID 16611631.
• Weidemann W, Stelzl U, Lisewski U, et al. (2007). "The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis". FEBS Lett. 580 (28–29): 6649–54. doi:10.1016/j.febslet.2006.11.015. PMID 17118363.