Cysteine lyase

In enzymology, a cysteine lyase (EC 4.4.1.10) is an enzyme that catalyzes the chemical reaction

L-cysteine + sulfite L-cysteate + hydrogen sulfide
cysteine lyase
Identifiers
EC number4.4.1.10
CAS number9079-86-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are L-cysteine and sulfite, whereas its two products are L-cysteate and hydrogen sulfide.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase (adding sulfite L-cysteate-forming). Other names in common use include cysteine (sulfite) lyase, and L-cysteine hydrogen-sulfide-lyase (adding sulfite). This enzyme participates in cysteine metabolism and taurine metabolism. It employs one cofactor, pyridoxal phosphate.

References

    • Tolosa EA, Chepurnova NK, Khomutov RM, Severin ES (1969). "Reactions catalysed by cysteine lyase from the yolk sac of chicken embryo". Biochim. Biophys. Acta. 171 (2): 369–71. doi:10.1016/0005-2744(69)90174-0. PMID 5813025.


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