Clofedanol
Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.[1] It is marketed in Canada under the trade name Ulone.GM Pharmaceuticals owns the patents to Chlophedianol and was the first company to launch the cough suppressant in the United States archive-date = 2009-08-21 | url-status = dead }}</ref> Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[2] and its safety and efficacy data are limited.
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Oral |
| ATC code | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.011.219  |
| Chemical and physical data | |
| Formula | C17H20ClNO |
| Molar mass | 289.80 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  | |
Synthesis
Clofedanol synthesis: R. Lorenz and H. Henecka, U.S. Patent 3,031,377 (1962).
gollark: I see.
gollark: Also, actual admins may need powers like IP-ban, arbitrary database beeing, sitewide config, and debug logs.
gollark: The existence of a user profile page.
gollark: Because it's quite useful?!
gollark: How do you make it ...ify at the right place?
See also
References
- "Clofedanol" (in French). BIAM. 1998-07-24. Retrieved 2007-04-15.
- "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.