Cheryll Tickle

Cheryll Anne Tickle CBE FRS FRSE FMedSci[2] is a distinguished British scientist, known for her work in developmental biology and specifically for her research into the process by which vertebrate limbs develop ab ovo. She is an Emeritus Professor at the University of Bath.[6][7]

Cheryll Tickle
Born
Cheryll Anne Tickle

(1945-01-18) 18 January 1945[1]
Alma mater
Awards
Scientific career
FieldsDevelopmental biology
Institutions
ThesisQuantitative studies on the positioning of cells in aggregates (1970)
InfluencedJeremy Farrar[4][5]
Websitewww.bath.ac.uk/bio-sci/contacts/academics/cheryll_tickle

Education

Tickle was educated at the University of Cambridge graduating with a Master of Arts degree in 1967, and received her Ph.D. from the University of Glasgow in 1970.[8][9]

Career

She worked as a postdoctoral researcher at Yale University, as a lecturer and reader at the Middlesex Hospital Medical School, and (after Middlesex merged with it in 1987) a reader and professor at University College London. She then moved to the University of Dundee in 1998, where she became Foulerton Professor of the Royal Society in 2000, and moved again to the University of Bath in 2007, retaining the Foulerton Professor title.[10][11]

Research

Tickle's research in Developmental Biology investigates how single cells, the fertilised egg, gives rise to a new individual during embryogenesis.[12][13][14][15][16][17][18][19][20][21][22][23][24][25]

Awards and honours

Tickle was elected as a fellow of the Royal Society in 1998, a fellow of the Royal Society of Edinburgh in 2000, a fellow of the Academy of Medical Sciences in 2001, and a member of the European Molecular Biology Organisation in 2001. In 2004 the University of St. Andrews awarded her an honorary doctorate. In 2005 she was named a Commander of The Most Excellent Order of the British Empire (CBE).[26] She also serves as a governor of the Caledonian Research Foundation.[27] Her nomination for the Royal Society reads:

Distinguished for her contribution to developmental biology. She demonstrated a quantitative relationship between the signal from the polarizing region in the embryo limb and the pattern digits, and that a similar signal was present in mammals. She discovered that local application of retinoic acid can mimic the signal from the polarizing region. Both these signals were shown to control homeobox gene expression. She has now shown that the signal from the apical ridge which is essential for limb development is a fibroblast growth factor. Her work is characterized by outstanding experimental skill, design and interpretation.[2]

Personal life

Tickle married John Gray in 1979.[1]

gollark: That isn't the halting problem and I disagree.
gollark: Regular polyhedra.
gollark: Do you know what that is?
gollark: They're meant to test some underlying general intelligence factor. Correlates quite well with stuff.
gollark: 55 would be ridiculous, that's 3 standard deviations.

References
  1. "TICKLE, Prof. Cheryll Anne". Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.(subscription required)
  2. "EC/1998/37: Tickle, Cheryll Anne". London: The Royal Society. Archived from the original on 16 July 2014. Retrieved 17 July 2014.
  3. Professor Cheryll Tickle FRS FRSE FMedSci
  4. Jeremy Farrar intervied on the Life Scientific by Jim Al-Khalili, BBC Radio 4 2014-07-15
  5. Tickle, C; Crawley, A; Farrar, J (1989). "Retinoic acid application to chick wing buds leads to a dose-dependent reorganization of the apical ectodermal ridge that is mediated by the mesenchyme". Development. 106 (4): 691–705. PMID 2562664.
  6. List of publications from Microsoft Academic
  7. Cheryll Tickle's publications indexed by the Scopus bibliographic database. (subscription required)
  8. Tickle, Cheryll Anne (1970). Quantitative studies on the positioning of cells in aggregates (PhD thesis). University of Glasgow.
  9. Gosling, R.; Tickle, C.; Running, S. W.; Tandong, Y.; Dinnyes, A.; Osowole, A. A.; Cule, E. (2011). "Seven ages of the PhD". Nature. 472 (7343): 283–286. Bibcode:2011Natur.472..283G. doi:10.1038/472283a. PMID 21512550.
  10. Speaker profile, CDB Symposium 2005, Center for Developmental Biology, Japan.
  11. Faculty profile, Department of Biology and Biochemistry, Univ. of Bath. Archived 30 April 2009 at the Wayback Machine
  12. Tickle C (January 2006). "Making digit patterns in the vertebrate limb". Nat. Rev. Mol. Cell Biol. 7 (1): 45–53. doi:10.1038/nrm1830. PMID 16493412.
  13. Tickle C (September 2004). "The contribution of chicken embryology to the understanding of vertebrate limb development". Mech. Dev. 121 (9): 1019–29. doi:10.1016/j.mod.2004.05.015. PMID 15296968.
  14. Tickle C, Cole NJ (June 2004). "Morphological diversity: taking the spine out of three-spine stickleback". Curr. Biol. 14 (11): R422–4. doi:10.1016/j.cub.2004.05.034. PMID 15182689.
  15. Cole NJ, Tanaka M, Prescott A, Tickle C (December 2003). "Expression of limb initiation genes and clues to the morphological diversification of threespine stickleback". Curr. Biol. 13 (24): R951–2. doi:10.1016/j.cub.2003.11.039. PMID 14680650.
  16. Tickle C (April 2003). "Patterning systems--from one end of the limb to the other". Dev. Cell. 4 (4): 449–58. doi:10.1016/S1534-5807(03)00095-9. PMID 12689585.
  17. Brown WR, Hubbard SJ, Tickle C, Wilson SA (February 2003). "The chicken as a model for large-scale analysis of vertebrate gene function". Nat. Rev. Genet. 4 (2): 87–98. doi:10.1038/nrg998. PMID 12560806.
  18. Tickle C (2000). "Limb development: an international model for vertebrate pattern formation". Int. J. Dev. Biol. 44 (1): 101–8. PMID 10761854.
  19. Tickle C, Münsterberg A (August 2001). "Vertebrate limb development--the early stages in chick and mouse". Curr. Opin. Genet. Dev. 11 (4): 476–81. doi:10.1016/S0959-437X(00)00220-3. PMID 11448636.
  20. Clarke JD, Tickle C (August 1999). "Fate maps old and new". Nat. Cell Biol. 1 (4): E103–9. doi:10.1038/12105. PMID 10559935.
  21. Tickle C, Altabef M (August 1999). "Epithelial cell movements and interactions in limb, neural crest and vasculature". Curr. Opin. Genet. Dev. 9 (4): 455–60. doi:10.1016/S0959-437X(99)80069-0. PMID 10449346.
  22. Cohn MJ, Tickle C (July 1996). "Limbs: a model for pattern formation within the vertebrate body plan". Trends Genet. 12 (7): 253–7. doi:10.1016/0168-9525(96)10030-5. PMID 8763496.
  23. Niswander, Lee (1994). "A positive feedback loop coordinates growth and patterning in the vertebrate limb". Nature. 371 (6498): 609–612. Bibcode:1994Natur.371..609N. doi:10.1038/371609a0. PMID 7935794.
  24. Niswander, L; Tickle, C; Vogel, A; Booth, I; Martin, G. R. (1993). "FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb". Cell. 75 (3): 579–87. doi:10.1016/0092-8674(93)90391-3. PMID 8221896.
  25. Cohn, M. J.; Izpisúa-Belmonte, J. C.; Abud, H; Heath, J. K.; Tickle, C (1995). "Fibroblast growth factors induce additional limb development from the flank of chick embryos". Cell. 80 (5): 739–46. doi:10.1016/0092-8674(95)90352-6. PMID 7889567.
  26. Honours and awards, College of Life Sciences, Univ. of Dundee. Archived 17 October 2008 at the Wayback Machine
  27. About the Caledonian Research Foundation. Archived 9 May 2008 at the Wayback Machine
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