CRKL

Crk-like protein is a protein that in humans is encoded by the CRKL gene.[5][6]

CRKL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZX, 2BZY, 2EO3, 2LQN, 2LQW
Identifiers
Aliases	CRKL, CRK like proto-oncogene, adaptor protein
External IDs	OMIM: 602007 MGI: 104686 HomoloGene: 38021 GeneCards: CRKL
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 20,917,407 bp[1] End 20,953,747 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,451,987 bp[2] End 17,487,434 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • signal transducer activity • RNA binding • cadherin binding • phosphotyrosine residue binding • identical protein binding Cellular component • cytoplasm • cytosol • endosome • extracellular exosome • nucleoplasm • neuromuscular junction • macromolecular complex • synapse • extrinsic component of postsynaptic membrane Biological process • animal organ morphogenesis • pattern specification process • JNK cascade • heart development • Ras protein signal transduction • GO:0007243 intracellular signal transduction • blood vessel development • parathyroid gland development • anterior/posterior pattern specification • positive regulation of cell proliferation • activation of MAPKK activity • thymus development • positive regulation of substrate adhesion-dependent cell spreading • activation of MAPK activity • regulation of cell growth • urogenital system development • neuron migration • B cell apoptotic process • negative regulation of protein phosphorylation • positive regulation of protein phosphorylation • regulation of leukocyte migration • outflow tract morphogenesis • lipid metabolism • spermatogenesis • single fertilization • synapse assembly • fibroblast growth factor receptor signaling pathway • male gonad development • regulation of gene expression • negative regulation of gene expression • dendrite development • cytokine-mediated signaling pathway • hippocampus development • cerebral cortex development • establishment of cell polarity • regulation of cell adhesion mediated by integrin • helper T cell diapedesis • cellular response to drug • reelin-mediated signaling pathway • positive regulation of Ras protein signal transduction • retinoic acid receptor signaling pathway • regulation of dendrite development • T cell receptor signaling pathway • cell chemotaxis • pharynx development • positive regulation of ERK1 and ERK2 cascade • cellular response to transforming growth factor beta stimulus • response to fibroblast growth factor • endothelin receptor signaling pathway • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • acetylcholine receptor signaling pathway • cerebellar neuron development • cellular response to interleukin-7 • positive regulation of glial cell migration • regulation of skeletal muscle acetylcholine-gated channel clustering • cranial skeletal system development • regulation of T cell migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1399	12929
Ensembl	ENSG00000099942	ENSMUSG00000006134
UniProt	P46109	P47941
RefSeq (mRNA)	NM_005207	NM_001277231 NM_007764
RefSeq (protein)	NP_005198	NP_001264160 NP_031790
Location (UCSC)	Chr 22: 20.92 – 20.95 Mb	Chr 16: 17.45 – 17.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.[7]

CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.[8][9]

Interactions

CRKL has been shown to interact with:

• Abl gene,[10][11][12]
• BCAR1,[13][14]
• BCR gene,[11][15][16][17]
• CBLB,[18]
• CD117,[19][20]
• CD34,[21]
• Cbl gene,[10][20][22][23][24][25][26][27][28][29]
• Dock2,[30]
• EPOR,[22][31]
• GAB1,[32]
• GAB2,[33]
• INPP5D,[31]
• MAP4K1,[34][35][36]
• MAP4K5,[37]
• NEDD9,[10][14][28][38]
• PIK3R2,[20]
• Paxillin[39][40]
• RAPGEF1,[10][22][32][41][42][43][44]
• RICS,[45]
• STAT5A,[46]
• Syk,[47] and
• WAS.[47]

See also

• Crk

References

1. GRCh38: Ensembl release 89: ENSG00000099942 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006134 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ten Hoeve J, Morris C, Heisterkamp N, Groffen J (September 1993). "Isolation and chromosomal localization of CRKL, a human crk-like gene". Oncogene. 8 (9): 2469–74. PMID 8361759.
6. Senechal K, Halpern J, Sawyers CL (September 1996). "The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene". The Journal of Biological Chemistry. 271 (38): 23255–61. doi:10.1074/jbc.271.38.23255. PMID 8798523.
7. "Entrez Gene: CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like".
8. Matsuki T, Pramatarova A, Howell BW (June 2008). "Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis". Journal of Cell Science. 121 (11): 1869–75. doi:10.1242/jcs.027334. PMC 2430739. PMID 18477607.
9. Park TJ, Curran T (December 2008). "Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway". The Journal of Neuroscience. 28 (50): 13551–62. doi:10.1523/JNEUROSCI.4323-08.2008. PMC 2628718. PMID 19074029.
10. Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (November 1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)". Journal of Immunology. 161 (10): 5555–63. PMID 9820532.
11. Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ (January 1997). "Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation". Blood. 89 (1): 297–306. doi:10.1182/blood.V89.1.297. PMID 8978305.
12. Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites". Genes & Development. 8 (7): 783–95. doi:10.1101/gad.8.7.783. PMID 7926767.
13. Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD (October 1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". The Journal of Biological Chemistry. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
14. Astier A, Manié SN, Law SF, Canty T, Haghayghi N, Druker BJ, Salgia R, Golemis EA, Freedman AS (December 1997). "Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells". Leukemia & Lymphoma. 28 (1–2): 65–72. doi:10.3109/10428199709058332. PMID 9498705.
15. Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID 9747873.
16. Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ (March 1999). "CRKL binding to BCR-ABL and BCR-ABL transformation". Leukemia & Lymphoma. 33 (1–2): 119–26. doi:10.3109/10428199909093732. PMID 10194128.
17. Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA (June 2004). "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase". Molecular and Cellular Biology. 24 (11): 4685–95. doi:10.1128/MCB.24.11.4685-4695.2004. PMC 416425. PMID 15143164.
18. Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC (February 1999). "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation". Oncogene. 18 (5): 1147–56. doi:10.1038/sj.onc.1202411. PMID 10022120.
19. van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10): 3406–13. doi:10.1182/blood.V96.10.3406. PMID 11071635.
20. Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.
21. Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ (June 2001). "The adapter protein CrkL associates with CD34". Blood. 97 (12): 3768–75. doi:10.1182/blood.v97.12.3768. PMID 11389015.
22. Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O (October 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochemical and Biophysical Research Communications. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID 9344843.
23. Alsayed Y, Modi S, Uddin S, Mahmud N, Druker BJ, Fish EN, Hoffman R, Platanias LC (July 2000). "All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells". Experimental Hematology. 28 (7): 826–32. doi:10.1016/s0301-472x(00)00170-3. PMID 10907644.
24. Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.
25. Park RK, Kyono WT, Liu Y, Durden DL (May 1998). "CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling". Journal of Immunology. 160 (10): 5018–27. PMID 9590251.
26. Taher TE, Tjin EP, Beuling EA, Borst J, Spaargaren M, Pals ST (October 2002). "c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". Journal of Immunology. 169 (7): 3793–800. doi:10.4049/jimmunol.169.7.3793. PMID 12244174.
27. Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL (April 1999). "Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages". Journal of Leukocyte Biology. 65 (4): 523–34. doi:10.1002/jlb.65.4.523. PMID 10204582.
28. Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD (May 1997). "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". The Journal of Biological Chemistry. 272 (22): 14320–6. doi:10.1074/jbc.272.22.14320. PMID 9162067.
29. Gesbert F, Garbay C, Bertoglio J (February 1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells". The Journal of Biological Chemistry. 273 (7): 3986–93. doi:10.1074/jbc.273.7.3986. PMID 9461587.
30. Nishihara H, Maeda M, Oda A, Tsuda M, Sawa H, Nagashima K, Tanaka S (December 2002). "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines". Blood. 100 (12): 3968–74. doi:10.1182/blood-2001-11-0032. PMID 12393632.
31. Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O (August 2001). "CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling". The Journal of Biological Chemistry. 276 (35): 33282–90. doi:10.1074/jbc.M102924200. PMID 11443118.
32. Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM (April 2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry. 275 (15): 10772–8. doi:10.1074/jbc.275.15.10772. PMID 10753869.
33. Crouin C, Arnaud M, Gesbert F, Camonis J, Bertoglio J (April 2001). "A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners". FEBS Letters. 495 (3): 148–53. doi:10.1016/s0014-5793(01)02373-0. PMID 11334882.
34. Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (October 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432.
35. Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (February 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Molecular and Cellular Biology. 19 (2): 1359–68. doi:10.1128/MCB.19.2.1359. PMC 116064. PMID 9891069.
36. Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (June 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". The Journal of Biological Chemistry. 276 (22): 18908–14. doi:10.1074/jbc.M101485200. PMID 11279207.
37. Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". Blood. 95 (3): 776–82. doi:10.1182/blood.V95.3.776.003k23_776_782. PMID 10648385.
38. Manié SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS (February 1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The Journal of Biological Chemistry. 272 (7): 4230–6. doi:10.1074/jbc.272.7.4230. PMID 9020138.
39. Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB (December 1995). "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells". The Journal of Biological Chemistry. 270 (49): 29145–50. doi:10.1074/jbc.270.49.29145. PMID 7493940.
40. Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–45. doi:10.1128/MCB.21.16.5332-5345.2001. PMC 87257. PMID 11463817.
41. Grumbach IM, Mayer IA, Uddin S, Lekmine F, Majchrzak B, Yamauchi H, Fujita S, Druker B, Fish EN, Platanias LC (February 2001). "Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells". British Journal of Haematology. 112 (2): 327–36. doi:10.1046/j.1365-2141.2001.02556.x. PMID 11167825.
42. Ahmad S, Alsayed YM, Druker BJ, Platanias LC (November 1997). "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein". The Journal of Biological Chemistry. 272 (48): 29991–4. doi:10.1074/jbc.272.48.29991. PMID 9374471.
43. Smit L, van der Horst G, Borst J (April 1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". The Journal of Biological Chemistry. 271 (15): 8564–9. doi:10.1074/jbc.271.15.8564. PMID 8621483.
44. Wu C, Lai CF, Mobley WC (August 2001). "Nerve growth factor activates persistent Rap1 signaling in endosomes". The Journal of Neuroscience. 21 (15): 5406–16. doi:10.1523/JNEUROSCI.21-15-05406.2001. PMID 11466412.
45. Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology. 22 (24): 8721–34. doi:10.1128/mcb.22.24.8721-8734.2002. PMC 139861. PMID 12446789.
46. Ota J, Kimura F, Sato K, Wakimoto N, Nakamura Y, Nagata N, Suzu S, Yamada M, Shimamura S, Motoyoshi K (November 1998). "Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin". Biochemical and Biophysical Research Communications. 252 (3): 779–86. doi:10.1006/bbrc.1998.9445. PMID 9837784.
47. Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H (May 2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk". Blood. 97 (9): 2633–9. doi:10.1182/blood.v97.9.2633. PMID 11313252.

Further reading

• Feller SM, Posern G, Voss J, Kardinal C, Sakkab D, Zheng J, Knudsen BS (December 1998). "Physiological signals and oncogenesis mediated through Crk family adapter proteins". Journal of Cellular Physiology. 177 (4): 535–52. doi:10.1002/(SICI)1097-4652(199812)177:4<535::AID-JCP5>3.0.CO;2-E. PMID 10092207.
• Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB (December 1995). "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells". The Journal of Biological Chemistry. 270 (49): 29145–50. doi:10.1074/jbc.270.49.29145. PMID 7493940.
• Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites". Genes & Development. 8 (7): 783–95. doi:10.1101/gad.8.7.783. PMID 7926767.
• Oda T, Heaney C, Hagopian JR, Okuda K, Griffin JD, Druker BJ (September 1994). "Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia". The Journal of Biological Chemistry. 269 (37): 22925–8. PMID 8083188.
• Smit L, van der Horst G, Borst J (April 1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". The Journal of Biological Chemistry. 271 (15): 8564–9. doi:10.1074/jbc.271.15.8564. PMID 8621483.
• Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD (October 1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". The Journal of Biological Chemistry. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
• Ingham RJ, Krebs DL, Barbazuk SM, Turck CW, Hirai H, Matsuda M, Gold MR (December 1996). "B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins". The Journal of Biological Chemistry. 271 (50): 32306–14. doi:10.1074/jbc.271.50.32306. PMID 8943292.
• Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ (January 1997). "Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation". Blood. 89 (1): 297–306. doi:10.1182/blood.V89.1.297. PMID 8978305.
• Manié SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS (February 1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The Journal of Biological Chemistry. 272 (7): 4230–6. doi:10.1074/jbc.272.7.4230. PMID 9020138.
• de Jong R, ten Hoeve J, Heisterkamp N, Groffen J (February 1997). "Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site". Oncogene. 14 (5): 507–13. doi:10.1038/sj.onc.1200885. PMID 9053848.
• Uemura N, Salgia R, Li JL, Pisick E, Sattler M, Griffin JD (March 1997). "The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376–85. doi:10.1038/sj.leu.2400590. PMID 9067577.
• Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.
• Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD (May 1997). "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". The Journal of Biological Chemistry. 272 (22): 14320–6. doi:10.1074/jbc.272.22.14320. PMID 9162067.
• Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B (May 1997). "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2". Oncogene. 14 (19): 2331–8. doi:10.1038/sj.onc.1201074. PMID 9178909.
• Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O (October 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochemical and Biophysical Research Communications. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID 9344843.
• Ahmad S, Alsayed YM, Druker BJ, Platanias LC (November 1997). "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein". The Journal of Biological Chemistry. 272 (48): 29991–4. doi:10.1074/jbc.272.48.29991. PMID 9374471.
• de Jong R, van Wijk A, Haataja L, Heisterkamp N, Groffen J (December 1997). "BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl". The Journal of Biological Chemistry. 272 (51): 32649–55. doi:10.1074/jbc.272.51.32649. PMID 9405482.
• Gesbert F, Garbay C, Bertoglio J (February 1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells". The Journal of Biological Chemistry. 273 (7): 3986–93. doi:10.1074/jbc.273.7.3986. PMID 9461587.

External links

• Human CRKL genome location and CRKL gene details page in the UCSC Genome Browser.