CLDN15

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene.[5] It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.[6]

CLDN15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4P79
Identifiers
Aliases	CLDN15, claudin 15
External IDs	OMIM: 615778 MGI: 1913103 HomoloGene: 8646 GeneCards: CLDN15
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 101,232,092 bp[1] End 101,238,820 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 136,966,616 bp[2] End 136,975,858 bp[2]
Gene ontology Molecular function • structural molecule activity • identical protein binding Cellular component • integral component of membrane • cell junction • cell membrane • lateral plasma membrane • membrane • bicellular tight junction Biological process • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules • ion transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	24146	60363
Ensembl	ENSG00000106404	ENSMUSG00000001739
UniProt	P56746	Q9Z0S5
RefSeq (mRNA)	NM_138429 NM_001185080 NM_014343	NM_021719
RefSeq (protein)	NP_001172009 NP_055158	NP_068365
Location (UCSC)	Chr 7: 101.23 – 101.24 Mb	Chr 5: 136.97 – 136.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000106404 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001739 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CLDN15 claudin 15".
6. Database, GeneCards Human Gene. "CLDN15 Gene - GeneCards | CLD15 Protein | CLD15 Antibody". www.genecards.org. Retrieved 2017-04-14.

External links

• Human CLDN15 genome location and CLDN15 gene details page in the UCSC Genome Browser.

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Yi X, Wang Y, Yu FS (2000). "Corneal epithelial tight junctions and their response to lipopolysaccharide challenge". Invest. Ophthalmol. Vis. Sci. 41 (13): 4093–100. PMID 11095601.
• Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. PMID 11912246.
• Colegio OR, Van Itallie CM, McCrea HJ, et al. (2002). "Claudins create charge-selective channels in the paracellular pathway between epithelial cells" (PDF). Am. J. Physiol., Cell Physiol. 283 (1): C142–7. doi:10.1152/ajpcell.00038.2002. PMID 12055082.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Van Itallie CM, Fanning AS, Anderson JM (2003). "Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins". Am. J. Physiol. Renal Physiol. 285 (6): F1078–84. doi:10.1152/ajprenal.00116.2003. PMID 13129853.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.