CLDN10

Claudin-10 is a protein that in humans is encoded by the CLDN10 gene.[5][6] It belongs to the group of claudins.

CLDN10
Identifiers
Aliases	CLDN10, CPETRL3, OSP-L, claudin 10, OSPL, HELIX
External IDs	OMIM: 617579 MGI: 1913101 HomoloGene: 5076 GeneCards: CLDN10
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q32.1 Start 95,433,604 bp[1] End 95,579,759 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 E4|14 62.55 cM Start 118,787,908 bp[2] End 118,875,489 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity • identical protein binding Cellular component • cytoplasm • integral component of membrane • cell junction • membrane • bicellular tight junction • cell membrane Biological process • cell adhesion • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules • ion transport • regulation of ion transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9071	58187
Ensembl	ENSG00000134873	ENSMUSG00000022132
UniProt	P78369	Q9Z0S6
RefSeq (mRNA)	NM_001160100 NM_006984 NM_182848	NM_001160096 NM_001160097 NM_001160098 NM_001160099 NM_021386 NM_023878
RefSeq (protein)	NP_001153572 NP_008915 NP_878268	NP_001153568 NP_001153569 NP_001153570 NP_001153571 NP_067361 NP_076367
Location (UCSC)	Chr 13: 95.43 – 95.58 Mb	Chr 14: 118.79 – 118.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Two alternatively spliced transcript variants that encode different isoforms have been identified for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000134873 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022132 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ip YC, Cheung ST, Lee YT, Ho JC, Fan ST (Nov 2007). "Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells". Mol Cancer Ther. 6 (11): 2858–67. doi:10.1158/1535-7163.MCT-07-0453. PMID 18025272.
6. "Entrez Gene: CLDN10 claudin 10".

External links

• Human CLDN10 genome location and CLDN10 gene details page in the UCSC Genome Browser.

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Kubota K, Furuse M, Sasaki H, et al. (2000). "Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions". Curr. Biol. 9 (18): 1035–8. doi:10.1016/S0960-9822(99)80452-7. PMID 10508613.
• Christian SL, McDonough J, Liu Cy CY, et al. (2002). "An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia". Genomics. 79 (5): 635–56. doi:10.1006/geno.2002.6765. PMID 11991713.
• Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes" (PDF). Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID 12067061.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cheung ST, Leung KL, Ip YC, et al. (2005). "Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma". Clin. Cancer Res. 11 (2 Pt 1): 551–6. PMID 15701840.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.