Biotinylated retinoids

Biotinylated retinoids are derivatives of retinol (vitamin A) carrying a biotin group for use in the isolation and purification of Retinol Binding Proteins involved in the visual cycle. The first biotinylated retinoid was synthesized in 2002 [1] and was used in the isolation and characterization of RPE65.[2]

Notes and references
  1. Nesnas, N.; Rando, R. R.; Nakanishi, K. (2002). "Synthesis of biotinylated retinoids for cross-linking and isolation of retinol binding proteins" (PDF). Tetrahedron. 58 (32): 6577. doi:10.1016/S0040-4020(02)00667-1.
  2. Jahng, W. J.; David, C.; Nesnas, N.; Nakanishi, K.; Rando, R. R. (2003). "A Cleavable Affinity Biotinylating Agent Reveals a Retinoid Binding Role for RPE65†". Biochemistry. 42 (20): 6159–6168. doi:10.1021/bi034002i. PMC 5506337. PMID 12755618.


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