Avelumab

Avelumab, sold under the brand name Bavencio, is a fully human monoclonal antibody developed by Merck KGaA and Pfizer as a pharmaceutical drug for use in immunotherapy, originally for the treatment of non-small-cell lung carcinoma (NSCLC).[3]

Avelumab
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetPD-L1
Clinical data
Trade namesBavencio
Other namesMSB0010718C
AHFS/Drugs.comMonograph
MedlinePlusa617006
License data
Pregnancy
category
  • AU: D [1]
  • US: N (Not classified yet) [1]
    Routes of
    administration    		Intravenous infusion
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    MetabolismProteolysis
    Elimination half-life6.1 days
    Identifiers
    CAS Number
    DrugBank
    ChemSpider
    • none
    UNII
    KEGG
    Chemical and physical data
    FormulaC6374H9898N1694O2010S44
    Molar mass143831.79 g·mol−1

    Common side effects include fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reactions, rash, decreased appetite and swelling of the limbs (peripheral edema).[4]

    Avelumab targets the protein programmed death-ligand 1 (PD-L1). It has received orphan drug designation by the European Medicines Agency (EMA) for the treatment of gastric cancer in January 2017.[5] The US Food and Drug Administration (FDA) approved it in March 2017 for Merkel-cell carcinoma.[4] an aggressive type of skin cancer. The EMA approved it in September 2017 for the same indication.[6]

    This is the first FDA-approved treatment for metastatic MCC, a rare, aggressive form of skin cancer.[4]

    Medical uses

    Merkel-cell carcinoma

    On 23 March 2017, the US Food and Drug Administration (FDA) granted accelerated approval to avelumab for the treatment of adults and children twelve years and older with metastatic Merkel-cell carcinoma (MCC).[7][4]

    Approval was based on data from an open-label, single-arm, multi-center clinical trial (JAVELIN Merkel 200 trial). All patients had histologically confirmed metastatic MCC with disease progression on or after chemotherapy administered for metastatic disease.[8]

    ORR was assessed by an independent review committee according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. The overall response rate (ORR) was 33% (95% confidence interval [CI]: 23.3, 43.8), with 11% complete and 22% partial response rates. Among the 29 responding patients, the response duration ranged from 2.8 to 23.3+ months with 86% of responses durable for 6 months or longer. Responses were observed in patients regardless of PD-L1 tumor expression or presence of Merkel cell polyomavirus.[8]

    Contraindications

    No contraindications have been specified.[9]

    Side effects

    The most common serious adverse reactions to avelumab are immune-mediated adverse reactions (pneumonitis, hepatitis, colitis, adrenal insufficiency, hypo- and hyperthyroidism, diabetes mellitus, and nephritis) and life-threatening infusion reactions. Among the 88 patients enrolled in the JAVELIN Merkel 200 trial, the most common adverse reactions were fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reaction, rash, decreased appetite, and peripheral edema. Serious adverse reactions that occurred in more than one patient in the trial were acute kidney injury, anemia, abdominal pain, ileus, asthenia, and cellulitis.[9][6]

    The most common serious risks are immune-mediated, where the body’s immune system attacks healthy cells or organs, such as the lungs (pneumonitis), liver (hepatitis), colon (colitis), hormone-producing glands (endocrinopathies) and kidneys (nephritis).[4] In addition, there is a risk of serious infusion-related reactions.[4] Patients who experience severe or life-threatening infusion-related reactions should stop using avelumab.[4] Women who are pregnant or breastfeeding should not take avelumab because it may cause harm to a developing fetus or a newborn baby.[4]

    Interactions

    As avelumab is an antibody, no pharmacokinetic interactions with other drugs are expected.[6]

    Pharmacology

    Mechanism of action

    Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). Formation of a PD-1/PD-L1 receptor/ligand complex leads to inhibition of CD8+ T cells, and therefore inhibition of an immune reaction. Immunotherapy aims at ceasing this immune blockage by blocking those receptor ligand pairs. In the case of avelumab, the formation of PD-1/PDL1 ligand pairs is blocked and CD8+ T cell immune response should be increased. PD-1 itself has also been a target for immunotherapy.[10] Therefore, avelumab belongs to the group of immune checkpoint blockade cancer therapies.

    History

    As of May 2015, according to Merck KGaA and Pfizer, avelumab has been in Phase I clinical trials for bladder cancer, stomach cancer, head and neck cancer, mesothelioma, NSCLC, ovarian cancer and renal cancer. For Merkel-cell carcinoma, Phase II has been reached and for NSCLC there is also a study in Phase III.[3]

    In May 2017, avelumab was approved in the United States for the treatment of adults and children twelve years and older with metastatic Merkel cell carcinoma (MCC), including those who have not received prior chemotherapy.[4] This is the first FDA-approved treatment for metastatic MCC, a rare, aggressive form of skin cancer.[4]

    The approval of avelumab was based on data from a single-arm trial of 88 patients with metastatic MCC who had been previously treated with at least one prior chemotherapy regimen.[4] The trial measured the percentage of patients who experienced complete or partial shrinkage of their tumors (overall response rate) and, for patients with a response, the length of time the tumor was controlled (duration of response).[4] Of the 88 patients who received Bavencio in the trial, 33 percent experienced complete or partial shrinkage of their tumors.[4] The response lasted for more than six months in 86 percent of responding patients and more than 12 months in 45 percent of responding patients.[4]

    The US Food and Drug Administration (FDA) granted the application for avelumab priority review, breakthrough therapy, and orphan drug designations.[4]

    The FDA granted accelerated approval of Bavencio to EMD Serono Inc.[4]

    In June 2020, avelumab was approved by the US Food and Drug Administration (FDA) for the indication of the maintenance treatment for people with locally advanced or metastatic urothelial carcinoma (UC) that has not progressed with first-line platinum-containing chemotherapy.[11]

    Efficacy of avelumab for maintenance treatment of urothelial carcinoma (UC) was investigated in the JAVELIN Bladder 100 trial (NCT02603432), a randomized, multi-center, open-label trial that enrolled 700 patients with unresectable, locally advanced or metastatic urothelial carcinoma that had not progressed with four to six cycles of first-line platinum-containing chemotherapy.[11] Patients were randomized (1:1) to receive either avelumab intravenously every 2 weeks plus best supportive care (BSC) or BSC alone.[11] Treatment was initiated within 4-10 weeks after last chemotherapy dose.[11]

    gollark: For purposes.
    gollark: PHP string split.
    gollark: So obviously it's mine, and you should guess as such.
    gollark: It looks like my entry to the maze one.
    gollark: You know palaiologos can lie, right?

    References
    1. "Avelumab (Bavencio) Use During Pregnancy". Drugs.com. 29 May 2019. Retrieved 2 August 2020.
    2. "Bavencio- avelumab injection, solution, concentrate". DailyMed. 2 July 2020. Retrieved 2 August 2020.
    3. Merck-Pfizer Alliance. "Merck-Pfizer Alliance Avelumab Fact Sheet" (PDF). Retrieved 2 December 2015.
    4. "FDA approves first treatment for rare form of skin cancer". U.S. Food and Drug Administration (FDA). 23 March 2017. Retrieved 2 August 2020.
    5. "Public summary of opinion on orphan designation: Avelumab for the treatment of gastric cancer" (PDF). European Medicines Agency. 9 January 2017.
    6. "Bavencio: EPAR - Product Information" (PDF). European Medicines Agency. 18 September 2017.
    7. Pfizer, Merck KGaA fourth to market with PD-1/L1 inhibitor
    8. Kaufman HL, Russell JS, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, et al. (January 2018). "Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial". Journal for Immunotherapy of Cancer. 6 (1): 7. doi:10.1186/s40425-017-0310-x. PMC 5774167. PMID 29347993.
    9. "Bavencio Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists, Inc. 27 January 2020. Retrieved 2 August 2020.
    10. Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. (July 2013). "Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma". The New England Journal of Medicine. 369 (2): 134–44. doi:10.1056/NEJMoa1305133. PMC 4126516. PMID 23724846.
    11. "FDA approves avelumab for urothelial carcinoma maintenance treatment". U.S. Food and Drug Administration (FDA). 30 June 2020. Retrieved 2 August 2020. This article incorporates text from this source, which is in the public domain.
    • "Avelumab". Drug Information Portal. U.S. National Library of Medicine.
    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.