Apolipoprotein L
Apolipoprotein L (Apo L) belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.[1]
| Apolipoprotein L | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ApoL | ||||||||
| Pfam | PF05461 | ||||||||
| InterPro | IPR008405 | ||||||||
| |||||||||
Human proteins containing this domain
APOL1; APOL2; APOL3; APOL4; APOL5; APOL6; APOLD1;
gollark: I have a sick 4d1h egg; it's really unlikely to die if it becomes a hatchling, right?
gollark: Right now I'm just trying to compile a "high trade value" group so I can manage the ones which are good for breeding more easily.
gollark: I really should have done groups earlier. I know I have a bunch of cool stuff like SAltkins somewhere, but they're not labelled and I have a thousand dragons to sort through at this point.
gollark: ?
gollark: They should reach the AP in about 3 days.
References
- Arai H, Mimmack ML, Ryan M, Baba H, Navarro-ruiz J, Iritani S, Faull RL, Mckenna PJ, Jones PB, Starkey M, Emson PC, Bahn S (2002). "Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4680–4685. doi:10.1073/pnas.032069099. PMC 123707. PMID 11930015.
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