APOL3

Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene.[3][4]

APOL3
Identifiers
Aliases	APOL3, APOLIII, CG121, CG12_1, apoL-III, apolipoprotein L3
External IDs	OMIM: 607253 HomoloGene: 129701 GeneCards: APOL3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 36,140,330 bp[1] End 36,166,177 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • lipid binding • lipid transporter activity Cellular component • cytoplasm • extracellular region • membrane Biological process • lipoprotein metabolic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • lipid transport • inflammatory response • signal transduction • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80833	n/a
Ensembl	ENSG00000128284	n/a
UniProt	O95236	n/a
RefSeq (mRNA)	NM_014349 NM_030644 NM_145639 NM_145640 NM_145641 NM_145642	n/a
RefSeq (protein)	NP_055164 NP_085147 NP_663614 NP_663615 NP_663616 NP_663617	n/a
Location (UCSC)	Chr 22: 36.14 – 36.17 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000128284 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
4. "Entrez Gene: APOL3 apolipoprotein L, 3".

External links

• Human APOL3 genome location and APOL3 gene details page in the UCSC Genome Browser.

Further reading

• Horrevoets AJ, Fontijn RD, van Zonneveld AJ, et al. (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. PMID 10233894.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Duchateau PN, Pullinger CR, Cho MH, et al. (2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". J. Lipid Res. 42 (4): 620–30. PMID 11290834.
• Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue". Genomics. 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.