Amino acid transporter
An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.
| Transmembrane amino acid transporter protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Aa_trans | ||||||||
| Pfam | PF01490 | ||||||||
| InterPro | IPR013057 | ||||||||
| TCDB | 2.A.18 | ||||||||
| Membranome | 228 | ||||||||
| |||||||||
Families
There are several families that function in amino acid transport, some of these include:
- TC# 2.A.3 - Amino Acid-Polyamine-Organocation (APC) Superfamily
- TC# 2.A.18 - Amino Acid/Auxin Permease (AAAP) Family
- TC# 2.A.23 - Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
- TC# 2.A.26 - Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
- TC# 2.A.42 - Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
- TC# 2.A.78 - Branched Chain Amino Acid Exporter (LIV-E) Family
- TC# 2.A.95 - 6TMS Neutral Amino Acid Transporter (NAAT) Family
- TC# 2.A.118 - Basic Amino Acid Antiporter (ArcD) Family
- TC# 2.A.120 - Putative Amino Acid Permease (PAAP) Family
Solute carrier family examples
- (1) high affinity glutamate and neutral amino acid transporter[1]
- (3) heavy subunits of heteromeric amino acid transporters[2]
- (6) Bacterial Leucine Transporter (LeuT)[3]
- (7) cationic amino acid transporter/glycoprotein-associated[4]
- (15) proton oligopeptide cotransporter[5]
- (17) vesicular glutamate transporter[6]
- (18) vesicular amine transporter[7]
- (25) some mitochondrial carriers[8]
- (26) multifunctional anion exchanger[9]
- (32) vesicular inhibitory amino acid transporter[10]
- (36) proton-coupled amino acid transporter[11]
- (38) System A & N, sodium-coupled neutral amino acid transporter[12]
VIAAT
Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[13]
Human proteins containing this domain
SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6.
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See also
- Solute carrier family
- Amino acid transport
- Amino acid transport, acidic
- Amino acid transport, basic
- Amino acid transport disorder
- Amino acid
- Transporter Classification Database
References
- Kanai Y, Hediger MA (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflügers Arch. 447 (5): 469–479. doi:10.1007/s00424-003-1146-4. PMID 14530974.
- Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Arch. 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309.
- Singh SK, Piscitelli CL, Yamashita A, Gouaux E (2008). "A competitive inhibitor traps LeuT in an open-to-out conformation". Science. 322 (5908): 1655–1661. doi:10.1126/science.1166777. PMC 2832577. PMID 19074341.
- Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters" (PDF). Pflügers Arch. 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310.
- Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflügers Arch. 447 (5): 610–618. doi:10.1007/s00424-003-1101-4. PMID 12905028.
- Reimer RJ, Edwards RH (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflügers Arch. 447 (5): 629–635. doi:10.1007/s00424-003-1087-y. PMID 12811560.
- Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–640. doi:10.1007/s00424-003-1100-5. PMID 12827358.
- Palmieri F (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflügers Arch. 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172.
- Mount DB, Romero MF (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflügers Arch. 447 (5): 710–721. doi:10.1007/s00424-003-1090-3. PMID 12759755.
- Gasnier B (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflügers Arch. 447 (5): 752–755. doi:10.1007/s00424-003-1091-2. PMID 12750892.
- Boll M, Daniel H, Gasnier B (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflügers Arch. 447 (5): 776–779. doi:10.1007/s00424-003-1073-4. PMID 12748860.
- Mackenzie B, Erickson JD (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflügers Arch. 447 (5): 784–795. doi:10.1007/s00424-003-1117-9. PMID 12845534.
- [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003
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