Alphaentomopoxvirus

Alphaentomopoxvirus is a genus of viruses, in the family Poxviridae, in the subfamily Entomopoxvirinae. Coleoptera insects serve as natural hosts. There are currently seven species in this genus including the type species Melolontha melolontha entomopoxvirus.[1][2]

Alphaentomopoxvirus
Virus classification
(unranked): Virus
Realm: Varidnaviria
Kingdom: Bamfordvirae
Phylum: Nucleocytoviricota
Class: Pokkesviricetes
Order: Chitovirales
Family: Poxviridae
Subfamily: Entomopoxvirinae
Genus: Alphaentomopoxvirus
Type species
Melolontha melolontha entomopoxvirus

Taxonomy

Group: dsDNA

[2]

Structure

Viruses in Alphaentomopoxvirus are enveloped, with ovoid geometries. The diameter is around 250 nm. Genomes are linear, around 260-370kb in length.[1]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
AlphaentomopoxvirusOvoidEnvelopedLinearMonopartite

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell. Fusion with the plasma membrane to release the core into the host cytoplasm. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV). IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV). Mature virion can be occluded in spheroids composed of spheroidin proteinhost receptors, which mediates endocytosis. Replication follows the DNA strand displacement model. Dna templated transcription is the method of transcription. The virus exits the host cell by existing in occlusion bodies after cell death and remaining infectious until finding another host. Coleoptera insects serve as the natural host.[1]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
AlphaentomopoxvirusMonkeys; baboonsNoneGlycosaminoglycansLysis; budding; occlusionCytoplasmCytoplasmContact; insects
gollark: ++list_deleted æ
gollark: ++delete æ
gollark: ++delete avaritia and the ability to have it
gollark: UNPRESENTIZE IT!
gollark: no.

References
  1. "Viral Zone". ExPASy. Retrieved 12 June 2015.
  2. ICTV. "Virus Taxonomy: 2014 Release". Retrieved 12 June 2015.
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