4'-demethylrebeccamycin synthase
4'-demethylrebeccamycin synthase (EC 4.3.3.5, arcyriaflavin A N-glycosyltransferase, RebG) is an enzyme with systematic name 4'-demethylrebeccamycin D-glucose-lyase.[1][2] This enzyme catalyses the following chemical reaction
- 4'-O-demethylrebeccamycin + H2O dichloro-arcyriaflavin A + beta-D-glucose
| 4'-demethylrebeccamycin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.3.3.5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme catalyses a step in the biosynthesis of rebeccamycin.
References
- Ohuchi T, Ikeda-Araki A, Watanabe-Sakamoto A, Kojiri K, Nagashima M, Okanishi M, Suda H (April 2000). "Cloning and expression of a gene encoding N-glycosyltransferase (ngt) from Saccarothrix aerocolonigenes ATCC39243". The Journal of Antibiotics. 53 (4): 393–403. doi:10.7164/antibiotics.53.393. PMID 10866221.
- Zhang C, Albermann C, Fu X, Peters NR, Chisholm JD, Zhang G, Gilbert EJ, Wang PG, Van Vranken DL, Thorson JS (May 2006). "RebG- and RebM-catalyzed indolocarbazole diversification". ChemBioChem. 7 (5): 795–804. doi:10.1002/cbic.200500504. PMID 16575939.
External links
- 4'-demethylrebeccamycin+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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