3-chloro-D-alanine dehydrochlorinase

In enzymology, a 3-chloro-D-alanine dehydrochlorinase (EC 4.5.1.2) is an enzyme that catalyzes the chemical reaction

3-chloro-D-alanine + H2O pyruvate + chloride + NH3
3-chloro-D-alanine dehydrochlorinase
Identifiers
EC number4.5.1.2
CAS number78990-65-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 3-chloro-D-alanine and H2O, whereas its 3 products are pyruvate, chloride, and NH3.

This enzyme belongs to the family of lyases, specifically the class of carbon-halide lyases. The systematic name of this enzyme class is 3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming). Other names in common use include beta-chloro-D-alanine dehydrochlorinase, and 3-chloro-D-alanine chloride-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.

References

    • Nagasawa T, Ishii T, Yamada H (1988). "Physiological comparison of D-cysteine desulfhydrase of Escherichia coli with 3-chloro-D-alanine dehydrochlorinase of Pseudomonas putida CR 1-1". Archives of Microbiology. 149 (5): 413–6. doi:10.1007/BF00425580. PMID 3132906.
    • Yamada H, Nagasawa T, Ohkishi H, Kawakami B, Tani Y (June 1981). "Synthesis of D-cysteine from 3-chloro-D-alanine and hydrogen sulfide by 3-chloro-D-alanine hydrogen chloride-lyase (deaminating) of Pseudomonas putida". Biochemical and Biophysical Research Communications. 100 (3): 1104–10. doi:10.1016/0006-291X(81)91937-9. PMID 6791643.


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