3,4-dihydroxyphenylalanine reductive deaminase

3,4-dihydroxyphenylalanine reductive deaminase (EC 4.3.1.22, reductive deaminase, DOPA-reductive deaminase, DOPARDA) is an enzyme with systematic name 3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming).[1] This enzyme catalyses the following chemical reaction

L-dopa + 2 NADH 3,4-dihydroxyphenylpropanoate + 2 NAD+ + NH3
3,4-dihydroxyphenylalanine reductive deaminase
Identifiers
EC number4.3.1.22
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme participates in the L-phenylalanine-catabolism in the anaerobic phototrophic bacterium Rhodobacter sphaeroides OU5.

References

  1. Ranjith NK, Sasikala C, Ramana C (2007). "Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine". Research in Microbiology. 158 (6): 506–11. doi:10.1016/j.resmic.2007.04.008. PMID 17616348.
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