2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase
2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13, CarC) is an enzyme with systematic name (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase.[1][2] This enzyme catalyses the following chemical reaction
- (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O anthranilate + (2E)-2-hydroxypenta-2,4-dienoate
| 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.7.1.13 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme catalyses the third step in the aerobic degradation pathway of carbazole.
References
- Nojiri H, Taira H, Iwata K, Morii K, Nam JW, Yoshida T, Habe H, Nakamura S, Shimizu K, Yamane H, Omori T (January 2003). "Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10". Bioscience, Biotechnology, and Biochemistry. 67 (1): 36–45. doi:10.1271/bbb.67.36. PMID 12619671.
- Riddle RR, Gibbs PR, Willson RC, Benedik MJ (March 2003). "Purification and properties of 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole". Protein Expression and Purification. 28 (1): 182–9. doi:10.1016/S1046-5928(02)00676-9. PMID 12651123.
External links
- 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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