2-Thiouracil

2-Thiouracil
Names
	IUPAC name 2-Thioxo-1H-pyrimidin-4-one
Identifiers
CAS Number	141-90-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:348530 ;
ChEMBL	ChEMBL345768 ;
ChemSpider	1066108 ;
ECHA InfoCard	100.005.008
KEGG	C19304 ;
MeSH	Thiouracil
PubChem CID	1269845;
UNII	59X161SCYL ;
CompTox Dashboard (EPA)	DTXSID4021347 ;
	InChI InChI=1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) Key: ZEMGGZBWXRYJHK-UHFFFAOYSA-N ; InChI=1/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) Key: ZEMGGZBWXRYJHK-UHFFFAOYAK;
	SMILES O=C1C=CNC(=S)N1;
Properties
Chemical formula	C4H4N2OS
Molar mass	128.15 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

2-Thiouracil is a specific molecule consisting of a sulfated uracil.

Medical use

The substance is a historically relevant anti-thyroid preparation. Astwood E.B. used it in 1943 as therapy of Graves' disease for the first time.[1] It remains in use.

Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase.[2] Its use in recent times has been replaced by advent of more potent and safer antithyroid drugs. It occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs.[3]

gollark: Actually, it is binary but 64 bits.

gollark: - when a message is somethinged on a virtual channel, it is bridged based on the lookup table- when a virtual channel is unlinked from a real channel it removes it from the lookup table- when the lookup table entry for the inter-virtual-channel link contains 0 items, bridging stops

gollark: - these are added to a lookup table of some sort for inter-VC bridging - all the channels which are currently causing inter-VC bridging are stored

gollark: - when a Discord channel is added to a virtual channel, it checks which ones are already connected

gollark: - do the virtual channel thing

References

Gerabek, W. (2005). Enzyklopädie Medizingeschichte. p. 152. ISBN 978-3-11-015714-7.
Nagasaka, A.; Hidaka, H. (1976). "Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2-Mercaptoimidazole on Human Thyroid Iodide Peroxidase". Journal of Clinical Endocrinology & Metabolism. 43 (1): 152–8. doi:10.1210/jcem-43-1-152. PMID 947933.
https://pubchem.ncbi.nlm.nih.gov/compound/thiouracil

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[q1-1] Gerabek, W. (2005). Enzyklopädie Medizingeschichte. p. 152. ISBN 978-3-11-015714-7.

[2] Nagasaka, A.; Hidaka, H. (1976). "Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2-Mercaptoimidazole on Human Thyroid Iodide Peroxidase". Journal of Clinical Endocrinology & Metabolism. 43 (1): 152–8. doi:10.1210/jcem-43-1-152. PMID 947933.

[3] ttps://pubchem.ncbi.nlm.nih.gov/compound/thiouracil