1-hydroxy-2-naphthoate 1,2-dioxygenase

In enzymology, a 1-hydroxy-2-naphthoate 1,2-dioxygenase (EC 1.13.11.38) is an enzyme that catalyzes the chemical reaction

1-hydroxy-2-naphthoate + O2 (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate
1-hydroxy-2-naphthoate 1,2-dioxygenase
Identifiers
EC number1.13.11.38
CAS number85941-64-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 1-hydroxy-2-naphthoate and O2, whereas its product is (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate.

This enzyme participates in naphthalene and anthracene degradation. It employs one cofactor, iron.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 1-hydroxy-2-naphthoate dioxygenase, 1-hydroxy-2-naphthoate-degrading enzyme, and 1-hydroxy-2-naphthoic acid dioxygenase.

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References
    • Barnsley EA (April 1983). "Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate". Journal of Bacteriology. 154 (1): 113–7. PMC 217437. PMID 6833175.
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