Looks Cassandra uses "java native" storage database format (keystore) to keep cryptographic keys, certificates and certificate keys. It's quite easy to manage this database with tool you mentioned above. There is comprehensive documentation at Oracle docs page https://docs.oracle.com/javase/8/docs/technotes/tools/windows/keytool.html
For your particular case, you need to follow these steps.
1) Import your RootCA cert to trusted authorities.
keytool -import -trustcacerts -alias rootCA -file rootCA.crt -keystore keystore.jks
2) Import your keypair to storage database. Easiest way with keytool is convert to pkcs12 format and then import to keystore
openssl pkcs12 -export -in mycert.pem -inkey mykey.pem > mykey.p12
Then convert this store into a Java key store:
keytool -importkeystore -srcstoretype pkcs12 -srckeystore mykey.p12 -destkeystore mykeystore.jks
I also can suggest nice GUI keystore tool (written in java) http://www.keystore-explorer.org/ if you like manage it graphically
Note that default keystore password is set to 'changeit
'. You are encouraged to change it.